益气养阴解毒方联合化疗治疗非小细胞肺癌临床研究  

Clinical Research on Qi-Replenishing,Yin-Nourishing and Detoxification Prescription Combined with Chemotherapy in the Treatment of Non-Small Cell Lung Cancer

作　　者：邱芝琳 葛信国[2] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210046 [2]常州市中医医院,江苏常州213000

出　　处：《中医学报》2014年第10期1397-1399,共3页Acta Chinese Medicine

基　　金：江苏省卫生厅资助项目(编号:20110329)

摘　　要：目的:探讨益气养阴解毒方联合化疗治疗晚期非小细胞肺癌的临床疗效。方法:随机将40例晚期非小细胞肺癌患者分为治疗组(益气养阴解毒方+化疗)和对照组(单纯化疗),每组各20例,治疗2个周期,每周期为21 d。2个周期后对各组治疗前后及两组治疗后的临床疗效、中医症状、体力状况、不良反应等指标进行比较,评价疗效。结果:临床疗效方面,两组比较无显著差异(P>0.05)。中医症状比较,治疗组治疗后有效率为70%,对照组治疗后有效率20%,治疗组明显优于对照组(P<0.05)。体力状况比较,两组治疗前无明显差异(P>0.05),治疗后治疗组疗效明显优于对照组(P<0.05)。不良反应比较,治疗组相对于对照组,不良反应出现的例数明显减少,其中白细胞、血红蛋白、呕吐等比较,差异显著(P<0.05),血小板、腹泻、谷丙转氨酶、肌酐比较,无明显差异(P>0.05)。结论:益气养阴解毒方联合化疗较单纯化疗治疗晚期非小细胞肺癌在改善患者体力状况,减轻中医症状方面具有明显优势,能一定程度上降低血液系统毒性,减轻消化道反应,提高晚期非小细胞肺癌患者化疗耐受性。Objective： To explore the Clinical therapeutic effect of Qi-Replenishing,Yin-Nourishing and Detoxification Prescription on advanced non-small-cell lung cancer. Methods： 40 patients with advanced NSCLC were randomly divided into the treatment group（ Qi-Replenishing,Yin-Nourishing and Detoxification Recipe ＋ chemotherapy） and the control group（ only chemotherapy）,each of 20 patients.The treatment was carried out in two cycles,each lasting for 21 days. After the two cycles,differences in indicators,including clinical therapeutic effect,TCM symptoms,physical conditions and toxic and side effects of each group between before and after treatment,as well as between the two groups after treatment were compared and the therapeutic effect was evaluated. Results： Comparing clinical curative effect of the two groups had no significant difference（ P〉0. 05）. In TCM symptoms,the total effective rate of the treatment group after treatment was 70%,the total effective rate of the control group after treatment was 20%,the treatment group was better than control group（ P〈0. 05）. In physical condition,two group has no obvious difference before the treatment（ P 〉0. 05）,after treatment the curative effect of treatment group was obviously better than that of the treatment group the control group（ P 〈0. 05）. In reducing the adverse reaction of chemotherapy,the treatment group has less cases than the control group. The difference of white blood cells,hemoglobin,nausea,vomiting in the two groups showed that the difference was statistically significant（ P〈 0. 05）. And the difference of platelets,diarrhea,ALT and creatinine in the two groups wasn＇t significant（ P 〉0. 05）. Conclusion： Treatment of advanced NSCLC with Qi-Replenishing,Yin-Nourishing and Detoxification Recipe combined with chemotherapy has significant advantages over treatment with chemotherapy only,in improving physical condition and relieving TCM symptoms of the patients. To a certain extent,it can reduce the toxicity of

关 键 词：非小细胞肺癌 益气养阴解毒方 化疗 

分 类 号：R273.42[医药卫生—中西医结合]