康肾口服液对阿霉素致大鼠肾病综合征模型的影响  

Influence of Shenkang Oral Liquid on Adriamycin Induced Nephrotic Syndrome Model in Rats

作　　者：张新际[1] 耿秀丽[1] 张正臣[1] 

机构地区：[1]中国人民解放军第371中心医院,河南新乡453000

出　　处：《中医学报》2014年第10期1465-1466,共2页Acta Chinese Medicine

基　　金：河南省科技攻关计划项目(编号:092102310202)

摘　　要：目的:观察康肾口服液对阿霉素致大鼠肾病综合征模型的血三酰甘油、总胆固醇、肌酐、尿素氮水平的影响。方法:取雄性大鼠84只,清洁级,适应性喂养7 d后,将84只大鼠按照体质量随机分成7组,其中6组一次性尾静脉注射阿霉素5 mg·kg-1复制肾病综合征模型,包括模型组、醋酸泼尼松片组、尿毒清颗粒组、大剂量康肾口服液组、中剂量康肾口服液组、小剂量康肾口服液组;另1组一次性尾静脉注射等量生理盐水作为空白对照组。结果:康肾口服液组和尿毒清颗粒组均可显著降低血肌酐水平(P<0.01)。大剂量、中剂量、小剂量康肾口服液组均可显著降低血尿素氮水平(P<0.01);以大剂量、中剂量康肾口服液组降低血三酰甘油、总胆固醇、肌酐、尿素氮的效果显著。结论:康肾口服液可显著降低阿霉素致大鼠肾病综合征模型的血三酰甘油、总胆固醇、肌酐、尿素氮水平。Objective： To observe the influence of Kangshen Oral Liquid on adriamycin induced nephrotic syndrome model of blood triglyceride,total cholesterol,creatinine,blood urea nitrogen level in rats. Methods： 84 male Wistar rats,clean,adaptive feeding a week later,84 rats were randomly divided into 7 groups according to weight,where in the 6 set of disposable intravenous injection of adriamycin nephrotic syndrome model of 5mg·kg^-1 building,including model group,prednisone acetate tablet,niaoduqing granule group,highdose,middle dose,small dose kangshen oral liquid group. Another group of disposable intravenous injection of normal saline as blank control group. Results： Kangshen oral liquid and niaoduqing granule group could significantly decrease the serum creatinine level（ P〈0. 01）; high-dose,middle-dose,small dose kangshen oral liquid groups could significantly reduce serum urea nitrogen level（ P〈0. 01）; And high-dose,middle-dose group kangshen oral liquid group had obvious effect on reducing serum triglyceride,total cholesterol,creatinine,urea nitrogen levels. Conclusion： Kangshen Oral Liquid can significantly reduce blood triglyceride,total cholesterol,creatinine,urea nitrogen level of adriamycin induced nephrotic syndrome model rats.

关 键 词：康肾口服液 阿霉素 肾病综合征 尿毒清颗粒 醋酸波尼松片 大鼠 

分 类 号：R285.5[医药卫生—中药学]