1-氯甲酰基-3-甲磺酰基-2-咪唑烷酮的工艺改进  

Technology Improvement of 1- chloro formyl- 3-methanesulfonyl- 2- imidazolidinone

作　　者：傅志慧 姜小林 吕拥军 郑育飞 应志洪 

机构地区：[1]浙江金华康恩贝生物制药有限公司,浙江金华321016

出　　处：《化工时刊》2014年第9期19-21,共3页Chemical Industry Times

摘　　要：通过对1-氯甲酰基-3-甲磺酰基-2-咪唑烷酮的酰氯化反应进行正交实验优选,确定反应的最佳温度。并通过中试进行放大实验优选,确定适合生产的最佳工艺参数。特定配比溶剂的酰氯化反应最佳反应温度为42℃～45℃,反应时间3小时,所得收率最高可达87%,质量可达99%（ HPLC）。该实验优选的反应工艺参数重复性好,所得收率最高,缩减了生产周期,使生产可在当天内完成,便于生产车间工作安排。By orthogonal experiment by acylation reaction of 1 - chloro formyl -3 - methanesulfonyl -2 -imidazolidinone,the optimum temperature was determined. And amplification experiments preferably by test, the opti-mum process parameters were determined for production. The optimum reaction temperature chloridization specific proportion of solvent was 42 ℃ ～45 ℃, reaction time 3 hours, the yield up to 87%, quality up to 99% （ HPLC） . The reaction process parameters of the preferred good repeatability, the highest yield, reduce the production cycle, the production was completed in a day, convenient production workshop arrangement.

关 键 词：咪唑烷酮 酰氯化 反应温度 正交实验 

分 类 号：TQ252.3[化学工程—有机化工]