Stereoselective Synthesis of （R）-Salmeterol via Asymmetric Cyanohydrin Reaction  

作　　者：LI Wei HUANG Hai JIN Xiaodong LIU Yujian XU Chaohang ZHU Hongjun 

机构地区：[1]Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China

出　　处：《Chemical Research in Chinese Universities》2014年第5期770-773,共4页高等学校化学研究（英文版）

摘　　要：The authors described a short and highly enantioselective route to （R）-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-（4-phenylbutoxy） hexyl methanesulfonate.The authors described a short and highly enantioselective route to （R）-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-（4-phenylbutoxy） hexyl methanesulfonate.

关 键 词：Asymmetric synthesis CATALYSIS CYANOHYDRIN ETHANOLAMINE METHANESULFONATE 

分 类 号：TQ453.4[化学工程—农药化工] O621.34[理学—有机化学]