血清胃蛋白酶原和抗Hp IgG抗体对消化性溃疡的临床意义  

Clinical significance of serum pepsinogen and anti-Hp Ig G antibody in the diagnosis of peptic ulcer

作　　者：赵兰静 刘春兴 安仙园 

机构地区：[1]上海华东疗养院检验科,江苏无锡214065

出　　处：《检验医学》2014年第11期1124-1127,共4页Laboratory Medicine

摘　　要：目的研究血清胃蛋白酶原(PG)和抗幽门螺杆菌(Hp)IgG抗体对消化性溃疡的临床价值。方法选取2007年10月至2012年12月期间,在上海华东疗养院体检时发现的消化性溃疡115例作为溃疡组,其中胃溃疡65例,十二指肠溃疡50例。对照组为同期健康体检者,共90名,其中男女比例及年龄均与溃疡组匹配。采用胶乳增强免疫透射比浊法检测PGⅠ、PGⅡ,并计算两者比值(PGⅠ/PGⅡ,PGR),利用酶联免疫吸附试验(ELISA)对受检者血清进行抗Hp IgG抗体检测。结果溃疡组中,PGⅠ和PGⅡ水平分别为(180.14±20.56)和(24.98±10.14)ng/m L,PGR为7.87±1.29,PGⅠ、PGⅡ及PGR明显高于对照组(P<0.05)。溃疡组和对照组抗Hp IgG抗体阳性率分别为77.4%和23.3%,差异具有统计学意义(P<0.05)。Hp阳性组的PGⅠ与PGⅡ分别为(165.35±22.14)及(20.75±11.26)ng/m L,PGR为7.64±2.03,明显高于Hp阴性组(P<0.05)。结论异常血清PG和抗Hp IgG抗体与消化性溃疡密切相关,并且可以作为消化性溃疡早期的筛查指标。Objective To investigate the clinical significance of serum pepsinogen （PG）and anti-Helicobacter pylori （Hp）IgG antibody in the diagnosis of peptic ulcer.Methods A total of 1 1 5 peptic ulcer patients （peptic ulcer group）were found by attending physical examination from October 2007 to December 201 2 in Huadong Sanatorium of Shanghai,including 65 cases of gastric ulcer and 50 cases of duodenal ulcer.A total of 90 healthy subjects were enrolled as controls,and the sex and age ratios were the same with those in peptic ulcer group.The levels of serum PGⅠ and PGⅡ were measured by latex-enhanced immunoturbidimetry,and the PGⅠ/Ⅱratio（PGR）was calculated.The serum anti-Hp IgG antibody was determined by enzyme-linked immunosorbent assay （ELISA）.Results In peptic ulcer group,the serum levels of PGⅠand PGⅡand PGR were （1 80.1 4 ±20.56）ng/mL,（24.98 ±1 0.1 4）ng/mL and 7.87 ±1 .29, respectively,which were significantly higher than those in control group （P〈0.05）.The positive rate of anti-Hp IgG antibody infection in peptic ulcer group was 77.4%,and that in control group was 23.3%,with statistical significance （P 〈0.05）.Serum PGⅠ and PG Ⅱlevels and PGR in HP positive group were （1 65.35 ±22.1 4）ng/mL,（20.75 ± 1 1 .26）ng/mL and 7.64 ±2.03,respectively,which were significantly higher than those in HP negative group （P 〈0.05）.Conclusions The serum PG and anti-Hp IgG antibody are related closely with peptic ulcer changes,and they can be used for the early screening of peptic ulcer.

关 键 词：胃蛋白酶原 抗幽门螺杆菌抗体 消化性溃疡 

分 类 号：R446.62[医药卫生—诊断学]