短葶山麦冬皂苷DT-13研究进展  

Advances in the research on DT-13,a saponin of Liriope muscari( Decne) Baily

作　　者：张媛媛[1] 宁华蓉 戚进[1] 寇俊萍[1] 余伯阳[1] 

机构地区：[1]中国药科大学中药复方研究室江苏省中药评价与转化重点实验室,南京211198

出　　处：《中国药科大学学报》2014年第5期593-598,共6页Journal of China Pharmaceutical University

基　　金：国家“十二五”重大新药创制科技重大专项资助项目(No.2012ZX09102201-015);国家自然科学基金资助项目(No.81274131);中国博士后基金资助项目(No.2012M521150)~~

摘　　要：短葶山麦冬[Liriope muscari(Decne)Baily]为山麦冬的基原植物之一。短葶山麦冬皂苷DT-13为其主要的活性成分,具有抗肿瘤转移、增强免疫、抗炎等多种药理活性。本文对短葶山麦冬皂苷DT-13的化学结构、提取分离、含量测定、药理活性和安全性评价等进行综述,进一步阐明短葶山麦冬皂苷DT-13的研究价值和应用前景。Liriope Muscari [ Liriope Muscari （Decne） Baily], one of the original plant-loading varieties of RadixLiriopes included in ＂China Pharmacopoeia＂ （2010 ed）, has various effects such as nourishing yin and promotingthe secretion of body fluid, moistening lung and clearing away the heart-fire with the dried root. The saponin,DT-13, is the major active constituent of Liriope tuberous root, with a variety of pharmacological activities includinganti-tumor metastasis, enhancing immunity, and anti-inflammation. In this paper, the chemical structure, contentdetermination, pharmacological activities and safety evaluation of DT-13 were summarized. It suggests that DT-13could be considered as a candidate drug with important research potentials and various promising application.

关 键 词：短葶山麦冬 麦冬皂苷 DT-13 药理活性 化学分析 

分 类 号：R284.1[医药卫生—中药学]