氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎84例临床研究  

Investigation of the effect of Loratadine associated with physiological seawater nasal wash spray in the treatment of children with allergic rhinitis

作　　者：潘彧 

机构地区：[1]广东省民航广州医院耳鼻咽喉科,广东广州510405

出　　处：《吉林医学》2014年第28期6243-6244,共2页Jilin Medical Journal

摘　　要：目的:探讨氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎的临床疗效及安全性。方法:将84例儿童变应性鼻炎患儿随机分成观察组和对照组,每组42例,两组均给予氯雷他定口服治疗,观察组加用生理性海水喷雾洗鼻液喷鼻治疗,两组疗程均为4周,观察两组患儿临床疗效及药物不良反应。结果:两组患儿治疗后症状总评分均较治疗前显著降低(t=5.863,4.318,P<0.01),观察组症状总评分(4.21±0.62)明显低于对照组(t=4.117,P<0.05)。观察组显效率(45.2%)、总有效率(92.9%)明显优于对照组(χ2=4.266,10.182,P<0.05)。结论:氯雷他定联用生理性海水喷雾洗鼻液治疗儿童变应性鼻炎安全、有效,适合临床推广应用。Objective To investigate the clinical efficacy and safety of loratadine associated with physiological seawater nasal wash spray in the treatment of children with allergic rhinitis. Method 84 children with allergic rhinitis were randomly divided into observation group and control group,42 cases in each group. All children were given oral loratadine,and children in the observation group was treated with physiological seawater nasal wash spray for four weeks,the clinical efficacy and adverse drug reactions were observed. Results The total symptom score in the two groups decreased significantly after treatment than before treatment（ t = 5. 863,4. 318,P〈0. 01）,total symptom score in the observation group（ 4. 21 ± 0. 62） was significantly lower than that in the control group（ t = 4. 117,P〈0. 05）. The tefficiency（ 45. 2%） and total efficiency（ 92. 9%） in the observation group were better than that in the control group（ χ^2= 4. 266,10. 182,P〈0. 05）. Conclusion Loratadine associated with physiological seawater nasal wash spray in the treatment of children with allergic rhinitis is safe and effective,and suitable for clinical application.

关 键 词：氯雷他定 生理性海水 洗鼻液 儿童 变应性鼻炎 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]