芬太尼联合异丙酚用于小儿无痛肠镜检查的临床分析  

Clinical Analysis of combined use of Fentanyl and Propofol in painless Colonoscopy in Children

作　　者：汪之沫[1] 孙志鹏[2] 

机构地区：[1]广东省深圳市南山区人民医院消化内科,广东深圳518052 [2]湖北省武汉市妇女儿童医疗保健中心麻醉科,湖北武汉430016

出　　处：《吉林医学》2014年第28期6274-6276,共3页Jilin Medical Journal

摘　　要：目的：探讨芬太尼联合异丙酚比单用异丙酚用于小儿肠镜检查的优越性。方法：选取96例拟行肠镜检查的患儿,年龄3-13岁,随机分成两组,每组48例,A组为芬太尼联合异丙酚组,静脉注射芬太尼1μg/kg,再静脉注射异丙酚2 mg/kg;B组单用异丙酚,静脉注射异丙酚2 mg/kg。记录分析患儿麻醉期心率（HR）、平均动脉压（MAP）和血氧饱和度（SpO2）的变化,以及异丙酚用药量、检查时间和清醒时间。结果：A、B两组患儿HR、MAP比麻醉前有所下降,差异有统计学意义（P〈0.05）;两组SpO2无明显变化,差异无统计学意义（P〉0.05）;A组异丙酚用药量明显少于B组,清醒时间明显短于B组,差异均有统计学意义（P〈0.05）;两组检查时间比较,差异无统计学意义（P〉0.05）。结论：芬太尼联合异丙酚用于小儿肠镜检查是安全有效的,优于单用异丙酚。Objective To investigate the advantage of combined use of Fentanyl and Propofol compared with only Propofol in pediatric painless colonoscopy. Method 96 children aged 3 to 13 years old undergoing colonoscopy were divided into two groups randomly. In group A（ propofol- fentanyl group： n = 48）,fentanyl 1 μg /kg iv was given first,then propofol 2 mg /kg iv was given. In group B（ propofol group： n = 48）,propofol 2 mg /kg iv was given. The changes of mean artery pressure（ MAP）,satuation of pulse oxygen（ SpO2）,heart rate（ HR）,dosage of propofol,examination time,recovery time were recorded and analyzed. Results MAP and HR in both groups had dropped obviously as compared with pre- operation（ P〈0. 05）; Changes of SpO2 in both groups were not significant（ P〉0. 05）; The dosage of propofol,recovery time in group A were much less than that in group B（ P〈0. 05）. Examination time in both groups had no significant differences（ P〉0. 05）. Conclusion Combining use of Fentanyl and Propofol is safe and effective in pediatric painless colonoscopy,and is better than only use of Propofol.

关 键 词：芬太尼 异丙酚 小儿无痛肠镜 

分 类 号：R726.1[医药卫生—儿科]