重组酸性成纤维细胞生长因子持续冲洗合并负压引流治疗难愈性创面  

Recombinant acidic fibroblast growth factor combined with negative pressure drainage in treatment of recalcitrant wounds

作　　者：李钢[1] 李小兵[1] 刘子健 刘光晶[1] 张静琦[1] 王爽[1] 

机构地区：[1]天津市第一中心医院整形与烧伤外科,天津300192

出　　处：《中国现代医生》2014年第30期10-12,共3页China Modern Doctor

摘　　要：目的研究重组人酸性成纤维细胞生长因子联合负压引流在难愈性创面治疗中的作用。方法收集2010年1月-2012年12月难愈性创面患者54例,按照交替法分为两组。试验组29例,使用酸性成纤维细胞生长因子持续冲洗（冲洗液中加入5支rh-aFGF）合并负压引流进行治疗;对照组25例,除冲洗液加生理盐水外,操作同试验组。记录治疗前后的创面及深部组织外露面积,并计算创面愈合率和伤腔容积减少值。结果试验组可见创面肉芽生长良好,骨肌腱外露面积缩小,伤腔容积减少值、创面愈合率均好于对照组（P〈0.05）,试验组创面经过短期换药后愈合或经植皮修复满意,对照组创面需要经过皮瓣移植或长时间换药才能完全愈合。结论本研究通过外源性持续补充aFGF,达到替代治疗的目的。Objective Study the effect of recombinant human acidic fibroblast growth factor combined suction drainage in the treatment of refractory wound. Methods Fifty-four patients with refractory wound were analyzed from January2010 to December 2012 and were randomly divided into the treatment group（n=29, treated with rh-aFGF washing during operation） and control group（n=25, treated with 0.9% NS）. Both groups were treated combined suction drainage treatment. Exposed areas of surface and deep tissue were recorded during the treatment, then the rate of deep wound healing and the rate of cavity volume improvement were calculated. Results Wound in the treatment group cured primarily, and the area of bone tendons exposure reduced. The rate of deep wound healing and the rate of cavity volume improvement in the treatment group were better than the control group（P〈0.05）. The treatment group all healed after short time dressing change. However, the control group all healed after long time dressing change or with skin flap transplantation. Conclusion By exogenous long-term supplementing aFGF and it can achieve the purpose of therapy.

关 键 词：重组人酸性成纤维细胞生长因子 难愈性创面 负压引流 皮瓣移植 

分 类 号：R459.9[医药卫生—治疗学]