水分对头孢地嗪钠中高分子聚合物含量的影响  

Effect of Water Content on High Molecular Polymers in Cefodizime Sodium

作　　者：牟微[1] 常明[1] 于宏伟[1] 王欣[1] 任蕾[1] 眭晓哲 

机构地区：[1]石家庄学院化工学院,河北石家庄050035 [2]石家庄科技职业学院,河北石家庄052165

出　　处：《煤炭与化工》2014年第9期21-22,152,共3页Coal and Chemical Industry

摘　　要：采用凝胶色谱法,考察了不同含水量对头孢地嗪钠中高分子聚合物含量的影响。色谱柱为SephadexG-10,流动相A为0.02mol·L^-1磷酸盐缓冲液（pH=7.0）;流动相B为超纯水;流速为1.0mL·min^-1;检测波长为254nm。头孢地嗪钠供试品溶液在10.536~34.461 mg·mL^-1范围内,溶液的浓度与高分子聚合物峰面积呈良好的线性关系（r=0.9986）。随着头孢地嗪钠含水量的增加,高分子聚合物的含量明显增加,研究证明水分是控制头孢地嗪钠高分子聚合物含量的关键因素。The effects of different water content on the high molecular polymers in cefodizime sodium were investigated by gel filtration chromatography. In the column （Sephadex G-10）,the mobile phase A was phosphate buffer solution with 0.02 mL·L^-1（pH=7.0）and the mobile phase B was ultrapure water, the flow rate was 1.0 mL·min^-1,and the detection wavelength was 254 nm. It was a good linear relation in range of 10.536 ~ 34.461 mL·L^-1 （r= 0.998 6） between the peak area ratio of high molecular polymers vs internal standard and its concentration. The content of polymer was increased significantly with the increase of water content in cefodizime sodium. It was founded that water was the key factor to control the concent of the high molecular polymers in cefodizime sodium.

关 键 词：头孢地嗪钠 水分 SephadexG-10 高分子聚合物 

分 类 号：TQ465.1[化学工程—制药化工]