前降钙素原在中国与马里恶性疟疾患者的比较研究  

Comparative study of procalcitonin in falciparum malaria patients between Chinese and Mali

作　　者：乔松[1] 屠政良[2] 郑彬荣[3] 王宇军[4] 张剑[5] 金戈[6] 

机构地区：[1]浙江医院ICU,杭州310013 [2]浙江大学第一附属医院胸外科,杭州310003 [3]天台县人民医院麻醉科,浙江台州317200 [4]浙江省立同德医院影像科,杭州310012 [5]浙江大学附属邵逸夫医院骨科,杭州310020 [6]浙江省人民医院药剂科,杭州310014

出　　处：《中华危重症医学杂志（电子版）》2014年第5期10-13,共4页Chinese Journal of Critical Care Medicine:Electronic Edition

摘　　要：目的探讨前降钙素原(PCT)对中国与马里危重恶性疟疾患者的影响。方法将63例恶性疟疾患者分成中国患者组(n=28)与马里患者组(n=35),分别记录所有患者治疗前及治疗后1、3、7 d的PCT水平、疟原虫数量及急性病生理学和长期健康评价(APACHE)Ⅱ评分。对疟原虫数量、APACHEⅡ评分与PCT水平关系采用Pearson相关分析。结果中马两组患者治疗后PCT水平(F=5.9、7.4,P均<0.05)、疟原虫数量(F=24.6、35.1,P均<0.05)及APACHEⅡ评分(F=29.8、37.4,P均<0.05)较治疗前均显著下降。且APACHEⅡ评分在治疗后个时间点比较,中国患者组较马里患者组下降更明显(t=15.9、17.2、23.4,P均<0.05)。Pearson相关分析提示PCT水平与各时间点疟原虫数量呈正相关(r=0.52、0.87、0.69、0.54,P均<0.05),但与APACHEⅡ评分不相关(P均>0.05)。结论 PCT能够反映中国与马里恶性疟疾患者疟原虫感染程度及治疗前后变化,对恶性疟疾诊断及指导治疗有一定帮助,但不能完全反映临床病情及疾病预后。Objective To investigate the value of procalcitonin （PC3） applying in several faleiparum malaria patients between Chinese and Mali. Methods Sixty-three falciparum malaria patients were divided into the Chinese group （28 eases） and Mali group （35 cases）. The level of PCT, plasmodium numbers and acute physiology and chronic health evaluation （APACHE） Ⅱ were recorded and compared before and 1, 3, 7 d after the treatment. The Pearson correlation was used to analyze the connection among plasmodium numbers, APACHE Ⅱand PCT. Results In the Chinese group and Mali group, the levels of PCT （F = 5.9, 7.4, all P 〈 0.05）, plasmodium numbers（F=24.6, 35.1, all P〈0.05） and APACHEⅡ （F=29.8, 37.4, all P〈0.05） on day 1, 3, 7 after the treatment all reduced as compared with those before the treatment. The APACHE Ⅱ in the Chinese group on day 1, 3, 7 after the treatment were much lower than those in the Mali group （t = 15.9, 17.2, 23.4, all P 〈 0.05）. The correlation between the level of PCT and plasmodium numbers were positive （r = 0.52, 0.87, 0.69, 0.54, all P〈 0.05）, but the APACHE Ⅱ showed no correlation with PCT （all P 〉 0.05）. Conclusions PCT can reflect the degree and change of infection in plasmodium malaria patients, which eould in part help to the diagnosisand therapy of several falciparum malaria. However, PCT cannot reflect the clinical condition and prognosis.

关 键 词：前降钙素原 疟疾 恶性 中国 马里 

分 类 号：R531.3[医药卫生—内科学]