气体信号分子CO和H_2S与抑郁症之间的相关研究  

Role of Plasma Carbon Monoxide and Hydrogen Sulfide in Depression

作　　者：程素满 陈金峰[2] 李志榕 

机构地区：[1]开封市第五人民医院,中国河南开封475003 [2]开封大学化学工程学院,中国河南开封475000

出　　处：《生命科学研究》2014年第5期407-410,共4页Life Science Research

基　　金：开封市科技局重点计划项目(130368)

摘　　要：为了探讨气体信号分子一氧化碳(carbon monoxide,CO)及硫化氢(hydrogen sulfide,H2S)与抑郁症之间的关系。选取抑郁症患者40例作为实验组,同时选取健康人40例作为对照组,两组在年龄、性别、肝功能、肾功能、血糖浓度等基本资料方面均无统计学差异(P>0.05),同时检测两组血浆CO、H2S的浓度和过氧化氢酶(catalase,CAT)的活性。研究发现实验组血浆CO含量和CAT活性均高于对照组,而H2S的含量低于对照组,差异均具有统计学意义(P<0.05);实验组血浆中CO和H2S的含量呈直线负相关关系,但和CAT没有直接关系。结果提示内源性CO、H2S与抑郁症之间存在着一定关系,氧化应激参与了反应。To investigate the role of carbon monoxide （CO） and hydrogen sulfide （H2S） in patients with depression. A total of 40 patients with depression and 40 healthy persons were employed in the current study, who did not show significant differences in age, sex, liver damage, renal function and blood glucose concentration （P〉0.05）. Plasma levels of CO and H2S concentrations as well as catalase activity were determined in both depression and healthy groups. The result showed both of plasma CO level and catalase activity in depression group were significantly higher than that in healthy group, while plasma H2S level was lower in patients with depression compared with the healthy group （P〈0.05）. Further data analysis indicated that the plasma level of CO and H2S in depression patients was negatively correlated. Briefly, endogenous plasma CO and H2S might play important roles in the regulation of depression, and oxidative stress was involved in the reaction.

关 键 词：抑郁症 一氧化碳(CO) 硫化氢(H2S) 

分 类 号：R395.4[哲学宗教—心理学]