miR-9的研究进展  

The Research Advances of miR-9

作　　者：刘艳玉[1] 蒋星军[2] 任彩萍[1] 

机构地区：[1]中南大学肿瘤研究所,中国湖南长沙410078 [2]中南大学湘雅医院神经外科,中国湖南长沙410078

出　　处：《生命科学研究》2014年第5期435-440,共6页Life Science Research

基　　金：国家973资助项目(2010CB833605);国家自然科学基金资助项目(81272972;81070993);教育部高校博士学科点专项科研基金(博导类)资助项目(20120162110059);中南大学贵重仪器设备开放共享基金资助项目;湖南省科技厅基金资助项目(2011FJ4051;2011FJ4180)

摘　　要：microRNAs（miRNAs）是真核生物中一类长度约为21-25 nt的非编码小分子RNA,在转录后水平调控基因的表达。作为microRNA中的一员——miR-9广泛存在于不同物种中。近年来的研究表明,它在体内发挥重要的生物学作用,参与调控生物体的生长发育及细胞的自我更新和多向分化等多种生理活动,而且其表达紊乱与多种肿瘤密切相关,在肿瘤的发生、侵袭及转移中起着举足轻重的作用。因此,miR-9的研究对于揭示基因表达的调控机理与疾病防治等具有重要意义。microRNA （miRNA） is a kind of non-coding small RNA about 21-25 nt in Eukaryotes. It can regulate the expression of genes at post-transcriptional level. As a member of miRNA, miR-9 exists in many different species. Recent researches have shown that miR-9 has important biological effects in vivo, for it is involved in a variety of physiological activities of the organism, such as the growth and development, selfrenewal and differentiation of cells. Moreover, its abnormal expression is associated with tumors and it has a critical role in tumor occurrence, invasion and metastasis. Therefore, the studies on miR-9 are of great significance in exploration of the regulatory mechanisms underlying gene expression, prevention and treatment of diseases.

关 键 词：MIR-9 细胞增殖 细胞分化 肿瘤 

分 类 号：Q74[生物学—分子生物学]