冠心病心绞痛患者血浆肿瘤坏死因子α和超敏C反应蛋白变化及其临床意义  

The clinical significance of plasma tumor necrosis factor α and high sensitive T C-reactive protein in patients with coronary heart disease

作　　者：朱洁莹[1] 刘丽军[1] 信栓力[1] 常超[1] 李敏[1] 王桂东[1] 李琴[1] 李雅琪[1] 魏金花[2] 

机构地区：[1]河北省邯郸市第一医院心内科,056002 [2]邯郸市第四医院心内科

出　　处：《中国综合临床》2014年第10期1030-1032,共3页Clinical Medicine of China

摘　　要：目的 探讨肿瘤坏死因子α（TNF-α）及超敏C反应蛋白（hs-CRP）在冠心病心绞痛发病机制中的作用.方法 选择冠状动脉造影确诊的心绞痛患者90例,分为不稳定型心绞痛（UAP）组46例,稳定型心绞痛（SAP）组44例;30例冠状动脉造影正常者作为对照组.采用酶联免疫吸附（ELISA）法检测血浆TNF-α、免疫浊度法检测hs-CRP浓度.结果 UAP组血浆TNF-α、hs-CRP水平为（34.87±9.59）ng/L、（2.34±0.81） mg/L,显著高于SAP组的（25.39±7.68） ng/L和（1.79±0.59） mg/L（P均＜0.01）,均明显高于对照组（13.87±5.24） ng/L、（1.15±0.35） mg/L（P均＜0.01）.结论 炎症反应可能参与了冠心病的发病过程,血浆TNF-α与hs-CRP对预测冠心病心绞痛的存在和发展有重要的临床意义.Objective To explore the role of tumor necrosis factor a（TNF-α） and high sensitive Creactive protein （hsCRP） in mechanism of patients with coronary heart disease （CHD）.Methods Ninety patients with diagnosed as angina pectoris by coronary angiography were selected our subjects.Among which,there were 46 cases with unstable angina pectoris （UAP group）,44 cases with stable angina patients （SAP group）.At the same time,30 cases with normal coronary angiography were selected and as control group.The level of TNF-α were measured by enzyme-linked immunosorbent assay,and the level of hsCRP was measured by immuno-nephelometry.Results The average plasma levels of TNF-α and hsCRP were （34.87 ± 9.59） ng/L,（2.34±0.81） mg/L in UAP group,significantly higher than those of SAP group （（25.39 ±7.68） ng/L,（1.79 ±0.59） mg/L; P 〈0.01）,and both were higher than those of control group （（13.87 ± 5.24） nig/L,（1.15 ±0.35） mg/L;P 〈0.01）.Conclusion Inflammatory might play an important role in the pathogenesis of CHD,and TNF-α and Hs-CRP show the significance in predicting occurrence of angina pectoris and development of CHD.

关 键 词：冠心病 心绞痛 肿瘤坏死因子Α 超敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]