Hcy、FA、VitB12及CA15-3联合检测在乳腺癌患者中的应用价值  

Clinical application value of combined detection of Hcy,FA,VitB12 and CA15-3in breast cancer patients

作　　者：高翠红[1] 赵玉萍[1] 

机构地区：[1]河北省唐山市妇幼保健院检验科,唐山063000

出　　处：《中国免疫学杂志》2014年第10期1408-1412,1412,共5页Chinese Journal of Immunology

摘　　要：目的:分析乳腺癌患者血清同型半胱氨酸(Hcy)、叶酸(FA)、维生素B12(VitB12)及CA15-3水平,并对其进行相关性分析。方法:选择乳腺癌患者55例,35例乳腺良性肿瘤患者和50例健康体检者做对照,分别以比色法测定Hcy水平,电化学发光法测定FA、VitB12及CA15-3水平。结果:乳腺癌患者Hcy、CA15-3水平明显高于对照组和乳腺良性肿瘤组,差异有显著性(P<0.05);乳腺良性肿瘤患者Hcy、CA15-3水平与正常对照组无显著差异(P>0.05),FA、VitB12水平乳腺癌组明显低于乳腺良性肿瘤组和正常对照组(P<0.05);乳腺良性肿瘤组与正常对照组FA、VitB12水平无明显差异(P>0.05)。癌症组FA随着临床分期的升高而递减,而Hcy、CA15-3随着临床分期的升高而递增。相关性分析表明,Hcy与FA、VitB12呈负相关(r=-0.341,r=-0.540)。CA15-3与Hcy呈正相关,与FA呈负相关(r=0.378,r=-0.361)。结论:联合测定乳腺癌患者血清Hcy、、CA15-3、FA、VitB12水平的变化对其病情诊断和预后判断具有重要临床价值。Objective：To evaluate the alternation of homocysteine（Hcy）,folic acid（FA）,CA15-3 and vitaminB12（VitB12） in patients with breast cancer and explore the correlation of them. Methods： The levels of FA,CA15-3 and VitB12 in serum of 55 breast cancer and 35 benign tumor of breast and 50 controls were measured by electro-chemiluminescence immunoassay（ECLI）,the Hcy levels were measured by colorimetric method. Results： Compared with the normal controls and benign tumor of breast cancer,there were some significantly changes in breast cancer patients including Hcy,CA15-3 increased and FA,VitB12 reduced（ P〉0. 05）,there were no significant differences in Hcy,FA,CA15-3,VitB12 levels between benign breast tumors and normal controls（P〈0. 05）. Companied with TNM stage increased,the levels of FA breast cancer groups decreased,the levels of Hcy,CA15-3 increased. The correlation analysis showed that Hcy was negatively correlated with FA and VitB12,（r =- 0. 341,r =- 0. 540）,CA15-3 was negatively correlated with FA,CA15-3 was postively correlated with Hcy（r = 0. 378,r =- 0. 361）. Conclusion： Serum Hcy,CA15-3,FA and VitB12 detection in patients with breast cancer are helpful in the severity judgment and regimen prognosis.

关 键 词：乳腺癌 同型半胱氨酸 叶酸 维生素B12 CA15-3 

分 类 号：R446.6[医药卫生—诊断学]