因子分析在中医方药量效关系研究中的应用  

Application of Factor Analysis in study on dose-effect relationship in traditional Chinese medicine prescription

作　　者：熊旺平[1] 周娴[1] 杜建强[1] 刘玉晖[1] 晏丽[1] 徐国良[1] 

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《中草药》2014年第19期2820-2823,共4页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划("973"计划)基金资助项目(2010CB530603);国家自然科学基金资助项目(61363042)

摘　　要：目的以经典方葛根芩连汤为例,对中医方药临床剂量与效应的变化规律进行研究。方法葛根芩连汤给药根据剂量分为9个组（1.65~28.05 g/kg）,每组同样的剂量给药6次,提取血清蛋白、血糖、胰岛素、糖化血红蛋白和胰岛素抵抗指数5项指标的因子。结果提取2个公共因子,方差贡献率分别为55.601%和24.157%。第1因子能代表血糖、糖化血红蛋白和胰岛素抵抗指数,而第2因子则适合代表血清蛋白和胰岛素。结论在分析葛根芩连汤治疗糖尿病的实验数据中,因子分析法取得了较好的效果,可以消除人为因素的干扰,是研究中药临床量效关系的有效方法。Objective By taking classical prescription of Gegen Qinlian Decoction （GQD） as the example, this research aims at studying the law of change between the clinical dosage of Chinese medicine and its effect. Methods The test groups were divided into nine groups according to nine different dosages of GQD （1.65-28.05 g/kg）. Each group was given the same dosage for six times. Then the factors of serum protein, blood sugar, insulin, glycated hemoglobins, and insulin resistance index were extracted. Results Two common factors were extracted and the variance contribution rates were 55.601% and 24.157%, respectively. The first factor could represent blood sugar, glycated hemoglobins, and insulin resistance index, while the second factor could represent serum protein and insulin. Conclusion Through analyzing the experimental data of GQD in the treatment of diabetes mellitus, it is found that Factor Analysis can achieve better results in eliminating the interference from human factors. Therefore, Factor Analysis is an effective and suitable method for studying the dose-effect relationship of Chinese material medica in clinical therapy.

关 键 词：因子分析 量效关系 方差贡献率 葛根芩连汤 糖尿病 

分 类 号：R285.5[医药卫生—中药学]