丹参素保护心血管系统的药理作用机制研究进展  

Pharmacologic mechanism for protective effects of danshensu on cardiovascular system

作　　者：王冰瑶[1] 吴晓燕[1] 樊官伟[1] 

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《中草药》2014年第17期2571-2575,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81273891);国家重点基础研究发展计划项目(2012CB518404)

摘　　要：心血管疾病已成为全球人类死亡的主要原因,丹参在中国有着数千年的应用历史,广泛用于治疗冠状动脉心脏疾病、心肌梗死、血液循环疾病等心血管疾病。越来越多的研究表明,丹参的主要水溶性成分丹参素具有多种药理作用,包括抗炎、抗肿瘤、神经保护、心肌保护、提高免疫力等。随着研究的深入,这些药理作用机制也逐渐清晰,分别从抗缺血-再灌注引起的心肌损伤、抗心肌梗死、抗动脉粥样硬化、抗高血脂、抗高血压、保护内皮细胞等方面对丹参素保护心血管系统的作用机制进行综述,为丹参素在临床中的应用及进一步研究提供理论依据。Cardiovascular disease is becoming the leading cause of death in the world. Salvia miltiorrhiza has a history of thousands of years in clinical therapy in China, which is widely used in the treatment of coronary heart disease, myocardial infarction, blood circulation diseases, and other cardiovascular diseases. More and more studies show that danshensu, the main water-soluble component in S. miltiorrhiza, has a variety of pharmacological effects, including inflammation and tumor inhibition, neuro and myocardial protection, immunity improving, and so on. With further research, the mechanisms of these pharmacological effects have been gradually clear. In this paper, we focus on the mechanism of danshensu on cardiovascular protection and provide a theoretical basis for the further study and clinical application of danshensu. The aspects of mechanism include inhibition on ischemia/reperfusion injury, hypertension, myocardial infarction, atherosclerosis, high cholesterol, and hypertension, protection of endothelial cells, and so on.

关 键 词：丹参素 心血管系统 缺血-再灌注损伤 心肌梗死 动脉粥样硬化 

分 类 号：R285[医药卫生—中药学]