注射用血栓通体外对家兔血小板聚集的影响  

Effects of Xueshuantong injection on platelet aggregation in rabbits in vitro

作　　者：王炎炎[1] 朱慧超 李来来[1] 肖扬[1] 王怡[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《中草药》2014年第18期2669-2672,共4页Chinese Traditional and Herbal Drugs

基　　金：“重大新药创制”科技重大专项项目(2012ZX 09102201-007);广西科学研究与技术开发计划(14125008-2-5)

摘　　要：目的研究注射用血栓通(冻干,主要成分为三七总皂苷,质量分数为95%)体外对二磷酸腺苷(ADP)、花生四烯酸(AA)、血小板活化因子(PAF)诱导家兔血小板聚集的影响。方法采用Born法,检测ADP、AA、PAF诱导的家兔血小板聚集率。结果与对照组比较,注射用血栓通7.2、14.4 mg/mL组能显著抑制ADP、AA、PAF诱导的兔血小板聚集率(P<0.01),注射用血栓通3.6 mg/mL组能显著抑制ADP诱导的兔血小板聚集率(P<0.01)。结论注射用血栓通具有体外抑制家兔血小板聚集的作用。Objective To study the effects of Xueshuantong injection （lyophilized, main component ofPanax Notoginsenosidum, total content of 95%） on platelet aggregation induced by adenosine diphosphate （ADP）, arachidonic acid （AA）, and platelet-activating factor （PAF） in rabbits. Methods Using the Born method, the platelet aggregation induced by ADP, AA, and PAF was detected. Results Compared with the control group, Xueshuantong injection （7.2 and 14.4 mg/mL） could significantly inhibit the platelet aggregation rate induced by ADP, AA, and PAF （P 〈 0.01）, Xueshuantong injection （3.6 mg/mL） could significantly inhibit the platelet aggregation rate induced by ADP （P 〈 0.01）. Conclusion Xueshuantong injection could inhibit the in vitro platelet aggregation of rabbits.

关 键 词：注射用血栓通 血小板聚集 三七总皂苷 花生四烯酸 血小板活化因子 

分 类 号：R285.5[医药卫生—中药学]