降血脂药非诺贝特的合成研究现状  

Synthetic Development of Hypolipidemic Drug Fenofibrate

作　　者：李敢[1,2] 

机构地区：[1]徐州工业职业技术学院化学工程技术学院,江苏徐州221140 [2]江苏省化工新材料工程技术研究开发中心,江苏徐州221140

出　　处：《广州化工》2014年第19期22-23,33,共3页GuangZhou Chemical Industry

摘　　要：非诺贝特是一种重要的降血脂药,具有广泛的用途。高效催化剂的选择是以非诺贝特酸与异丙醇为原料合成非诺贝特的关键环节。参考了近几年有关非诺贝特合成的文献,介绍了合成路线、无机酸、无机盐、固体酸等催化剂催化合成非诺贝特的工艺条件、分析了带水剂、醇酸摩尔比等因素对反应的影响,并指出了催化剂的研究发展方向。Fenofibrate was a kind of important hypolipidemic drug, with a wide range of uses. Choosing a kind of high efficient catalyst for synthesis of Fenofibrate with fenofibrate acid and isopropyl alcohol as raw materials was an important step. The literature on the synthesis of Fenofibrate in recent years was referenced, catalytic performance, optimization conditions and research status about the synthesis of Fenofibrate using the catalysts, such as inorganic acid, inorganic salt and solid superacid were introduced, the influence factors of water - carrying agent, molar ratio of acid and alcohol on the reaction were analyzed, and the direction of research and development of catalysts was pointed out.

关 键 词：非诺贝特酸 异丙醇 非诺贝特 酯化 

分 类 号：TQ620.63[化学工程—精细化工]