LC-MS/MS鉴定阿齐沙坦降解产物  

Identification of the Degradation Compounds of Azilsartan by LC-MS

作　　者：吴强[1] 陈金嫚 何广卫[1] 

机构地区：[1]合肥医工医药有限公司,安徽合肥230601 [2]广州博腾生物医药科技有限公司,广东广州510663

出　　处：《广州化工》2014年第19期105-107,共3页GuangZhou Chemical Industry

摘　　要：以1%甲酸溶液-乙腈为流动相,经C18柱(250 mm×4.6 mm,5μm)分离,通过串联ESI质谱在线检测,获得相关的色谱和质谱信息。根据研究结果推测光降解主要产物为1-((2'-1H-双吖丙啶-3-基-[1,1'-联苯]-4-基)甲基)-2-乙氧基-1H-苯并[d]咪唑-7-羧酸,酸降解主要产物为2-氧代-3-((2'-(5-氧代-4,5-二氢-1,2,4-噁二唑酮-3-基)-[1,1'-联苯]-4-基)甲基)-2,3-二氢-1H-苯并[d]咪唑-4-羧酸。The HPLC separation experiment.~ were performed on a C ls column （250 mm × 4.6 mm, 5 μm）, with 1% formic acid - acetonitrile as mobile phase. The analytics were determined by ESI - MS. The chromatograms and mass spectra of forced degradation products of azilsartan were obtained by LC - MS. The structure of impurities were confirmed as 1 - （ （2＇- （ 1H - diazirin - 3 - yl） - [ 1,1＇- biphenyl ] - 4 - yl） methyl） - 2 - ethoxy - 1H - benzo [ d ] imidazole - 7 - carboxylic acid, 2 - oxo - 3 - （ （ 2＇- （5 - 020 - 4,5 - dihydro - 1,2,4 - oxadiazol - 3 - yl ） - [ 1,1＇- biphenyl ] - 4 - yl） methyl） - 2,3 - dihydro - 1H - benzo[ d ] imidazole - 4 - carboxylic acid, respectively.

关 键 词：阿齐沙坦 降解产物 高效液相色谱-串联质谱 

分 类 号：R917[医药卫生—药物分析学]