三阴性乳腺癌新辅助化疗前Ki-67表达与病理完全反应相关性的Meta分析  

Relationship between the expression of Ki-67 and pathological complete response in triple-negative breast cancer before neoadjuvant chemotherapy:A Meta-analysis

作　　者：张莉[1] 龙行华[1] 

机构地区：[1]武汉大学中南医院检验科,武汉430071

出　　处：《检验医学与临床》2014年第19期2651-2653,共3页Laboratory Medicine and Clinic

基　　金：国家自然科学基金资助项目(30873044;81272372);教育部留学回国人员科研启动基金资助项目(教外司留[2011]1139号)

摘　　要：目的对三阴性乳腺癌新辅助化疗前Ki-67表达与病理完全反应相关性进行系统综合评价。方法从PubMed、中国期刊全文数据库及万方数据库中,检索有关Ki-67和三阴性乳腺癌新辅助化疗病理完全反应的文献,用风险比(RR)评价三阴性乳腺癌新辅助化疗前Ki-67和病理完全反应间的关系,用Rev-Man 5.2软件进行Meta分析。结果共纳入10篇文献(中文3篇,英文7篇),三阴性乳腺癌患者共649例。采用固定效应模型计算合并RR=4.04,95%CI=2.66-6.15(P<0.01)。结论化疗前Ki-67高表达的三阴性乳腺癌患者在新辅助化疗后,获得病理完全缓解率大约是Ki-67低表达组的4倍。Objective To systematically evaluate the relationship between the expression of Ki-67 and patho-logical complete response in triple-negative breast cancer （TNBC）before the neoadjuvant chemotherapy .Methods Articles about the association between the expression of Ki-67 before the neoadjuvant chemotherapy and pathological complete response were retrieved from PubMed ,CNKI and Wanfang database .The risk ratio （RR） was used to eval-uate the relationship between the expression of Ki-67 before the neoadjuvant chemotherapy and pathological complete response in TNBC .Rev-Man 5 .2 software was applied to perform the meta-analysis .Results A total of 10 articles （3 articles in Chinese and 7 articles in English） were eligible for the meta-analysis .There were 649 patients with triple-negative breast cancer .Thus ,the fix model was applied to calculate the pooled RR （RR= 4 .04 ,95% CI= 2 .66 -6 .15 ,P〈0 .01） .Conclusion It was about 4 times for the rate of pathological complete response in TNBC with the high-expression of Ki-67 compared with the low-expression Ki-67 before the neoadjuvant chemotherapy .

关 键 词：三阴性乳腺癌 新辅助化疗 KI-67 病理完全缓解 META分析 

分 类 号：R984[医药卫生—药品]