北京某院医院感染铜绿假单胞菌耐药性分析  

Analysis on the antimicrobial resistance of Pseudomonas aeruginosa causing nosocomial infection

作　　者：钱扬会[1] 郝秀红[1] 李艳君[1] 丁毅伟[1] 赵强元[1] 

机构地区：[1]海军总医院检验科,北京100048

出　　处：《检验医学与临床》2014年第19期2656-2657,共2页Laboratory Medicine and Clinic

基　　金：国家科技支撑计划项目(2013BAI17B05);军队医学科研十二五重大专项支撑项目(AWS11Z005-4)

摘　　要：目的分析临床送检标本中首次分离的铜绿假单胞菌(PAE)的耐药性,为临床医师合理用药提供科学依据。方法回顾性分析2012年1月至2012年12月海军总医院送检标本中首次分离的PAE,并进行药物敏感性分析。结果 271株铜绿假单胞菌中,痰标本检出率占首位,高达77.1%。PAE对临床常用抗菌药物均产生了不同程度的耐药性,对亚胺培南和美罗培南耐药率分别达到38.4%和26.9%,而对头孢曲松、头孢呋辛钠、氨苄西林/舒巴坦、头孢唑啉、头孢替坦、呋喃妥因和氨苄西林耐药率分别高达97.1%、98.2%、97.9%、99.4%、96.4%、100.0%、100.0%。结论应加强多重耐药PAE的动态监测,增强对各临床科室感染控制。Objective To investigate the antimicrobial resistance of Pseudomonas aeruginosa （PAE） causing nosocomial infection and provide evidence for clinical reasonable use of antibiotics .Methods Drug sensitivity and iso-lation rate of PAE from January 2012 to December 2012 was analyzed retrospectively .Results In 271 strains Pseudo-monas aeruginosa ,the detecion rate of sputum samples was the highest with the rate as 77 .1% .PAE presented differ-ent degree of resistance to clinical common antibacterial drugs .The resistance rate of Imipenem and Meropenem reach to 38 .4% and 26 .9% respectively ,The resistance rate to Ceftriaxone ,Cefuroxime ssdium ,ampicillin/sulbactam ,Ce-fazolin ,Cefotetan ,Nitrofurantoin and Ampicillin whereas as 97 .1% ,98 .2% ,97 .9% ,99 .4% ,96 .4% ,100 .0% , 100 .0% respectively .Conclusion Dynamical monitoring on the multiple-drug resistant of PAE should be strength-ened to control the nosocomial infection .

关 键 词：铜绿假单胞菌 耐药性 泛耐药 

分 类 号：R378.991[医药卫生—病原生物学]