α-硫辛酸对2型糖尿病心脏自主神经病变患者心率变异性的影响  

Effects ofα-Lipoic acid on heart rate variability in type 2 diabetes mellitus patients with cardiac autonmic neuropathy

作　　者：陈勇[1,2] 文重远[1] 金亚[2] 胡艺琼[2] 

机构地区：[1]武汉大学人民医院内分泌科,武汉430060 [2]湖北理工学院附属黄石市中心医院内分泌科,湖北黄石435002

出　　处：《检验医学与临床》2014年第19期2681-2683,共3页Laboratory Medicine and Clinic

摘　　要：目的观察α-硫酸锌对2型糖尿病(T2DM)心脏自主神经病变患者心率变异性(HRV)的影响。方法选择2012年6月至2013年12月武汉大学人民医院住院和门诊T2DM合并心脏自主神经病变患者86例为研究对象,随机分为治疗组44例和对照组42例。对照组患者仅给予通常的降糖、降脂和降压等治疗手段,治疗组患者在对照组基础上给予α-硫酸锌600mg静脉滴注,每天1次,总疗程4周。观察临床症状,并运用24h动态心电图检测所有患者在治疗前、后HRV指标的变化。结果治疗组HRV较治疗前明显提高,自主神经症状明显好转,与对照组相比,差异有统计学意义(P<0.05)。结论α-硫酸锌治疗糖尿病心脏自主神经病变的疗效显著,可改善患者HRV。Objective To evaluate the clinical effects of α-lipoic acid on heart rate variability （HRV） in type 2 diabetes mellitus （T2DM ） patients with cardiac autonomic neuropathy .Methods Eighty-six cases of T2DM patients with cardiac autonomic neuropathy were randomly divided into the treatment group （n=44） and the control group （n=42） .The control group was treated with traditional treatment of anti-diabetics ,anti-hyperlipidemia and anti-hy-pertension ,while the patients in the treatment group were administered with α-lipoic acid 600 mg intravenously guttae qd for 4 weeks .The changes of the HRV parameters in all patients were closely monitored with a 24-hoter .Results With the better altered physiopathologic syndromes ,the HRV parameters in the patients of the treatment group had a significant improvement after 4-week treatment as against before treatment ,and there were significances in compari-son with control group （P〈0 .05） .Conclusion α-lipoic acid is effective for cardiac autonomic neuropathy in patient with T2DM and it could improve patientsHRV and clinical symptoms .

关 键 词：α-硫酸锌 2型糖尿病 心率变异性 心脏自主神经病变 

分 类 号：R259.872[医药卫生—中西医结合]