降脂消斑片对鹌鹑动脉粥样硬化模型血脂的影响  

Effects of Jiang Zhi Xiao Ban Pill on Regulation of Blood Lipid in Quails with Atherosclerosis Model

作　　者：龙云[1] 吴群[2] 朱志宏 刘建和[1] 王敏[1] 晏程远[2] 程丑夫[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学,湖南长沙410208 [3]湖南九典制药有限公司,湖南长沙410031

出　　处：《中医药导报》2014年第12期16-18,22,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重大新药创制重大专项(2010ZX09101-103)

摘　　要：目的:观察降脂消斑片对鹌鹑动脉粥样硬化(AS)模型血脂的影响。方法:采用单纯高脂饲料喂养方法复制鹌鹑AS模型。分别给予降脂消斑片高、中、低剂量及阳性对照药物辛伐他汀片、脂降宁片治疗,观察其对血脂的影响。结果:降脂消斑片能明显降低高胆固醇饮食鹌鹑血清TC、TG及LDL-C含量,差异有统计学意义(P<0.05),并可升高血清Apo-A,降低血清Apo-B含量,提高Apo-A/Apo-B比值,差异均有统计学意义(P<0.05)。结论:降脂消斑片具有较强调节血脂作用。Objective： To observe the effects of Jiang Zhi Xiao Ban Pill（JZXBP） on regulation of blood lipid in quails with atherosclerosis （AS） model. Methods： Pure high cholesterol diet was applied to replicate models of AS in quails, which were re- spectively given high, middle and low dose of JZXBP, as well as the positive control drugs Simvastatin Tablets and Jiangzhining tablet,. The levels of plasma total cholesterol（TC）, triglyceride（TG）, low density lipoprotein-cholesterol （LDL-C）, high density lipoprotein-cholesterol （HDL-C）, apolipoprotein A（Apo-A） and apolipoprotein B （Apo-B） were observed. Results： JZXBP remarkably decreased the level of serum TC,TG,LDL-C,Apo-B（P〈0.05）, and increased the level of serum Apo-A and Apo-A/ Apo-B （P〈0.05）.Conclusion： JZXBP could play a stronger role in regulating blood lipid.

关 键 词：降脂消斑片 鹌鹑 动脉粥样硬化 调节血脂 

分 类 号：R285.5[医药卫生—中药学]