中药治疗变应性鼻炎的系统评价  

Systematic review of the effect of Chinese medicine on allergic rhinitis

作　　者：陈晴[1] 刘洋[1] 张勤修[2] 李昕蓉[1] 王晓培[1] 李敏[1] 禹云芝 

机构地区：[1]成都中医药大学,成都610072 [2]成都中医药大学附属医院耳鼻咽喉科,成都610072

出　　处：《中华中医药杂志》2014年第10期3071-3076,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81273985)~~

摘　　要：目的:评价中草药治疗变应性鼻炎的疗效和安全性。方法:计算机检索国内外相关数据库,手工检索《中华耳鼻咽喉头颈科杂志》、《中国中西医结合耳鼻咽喉科杂志》等,收集中药治疗变应性鼻炎的随机对照试验(RCT)。按纳入与排除标准筛选试验、提取资料和评价质量,而后采用RevMan 5.2.6软件进行统计分析。结果:共纳入11个临床研究,分为3个亚组,合计1 652例患者进行Meta分析。结果显示:临床总有效率RR=1.29,95%CI[1.08,1.54];鼻部症状总评分MD=-2.09,95%CI[-3.55,-0.62];复发率RR=0.31,95%CI[0.22,0.44];定性研究表明中药治疗变应性鼻炎能更有效的改善鼻部症状单项评分;安全性分析纳入4个研究,3个报道无明显不良反应,1个报道发生不良反应,两组间发生率无统计学差异。结论:目前证据证明中药治疗变应性鼻炎可提高临床疗效、改善患者鼻部症状,不良反应发生率小。Objective： To evaluate the efficacy and safety of Chinese medicine in the treatment of Allergic Rhinitis （AR）. Methods： The following databases and periodicals such as PubMed, MEDLINE, EBSCOhost, CNKI, VIP and CBM by computer retrieval, and Chinese Journal of Otorhinolaryngology Head and Neck Surgery and Chinese Journal of Otorhinolaryngology of Integrated Traditional and Western Medicine by manual retrieval were conducted to collect the randomized controlled trials （RCTs） about Chinese medicine in the treatment of AR. The trial screening, the data extraction and quality assessment of the RCTs were conducted following the inclusive criteria and exclusive criteria. Then the data was analyzed by RevMan 5.2.6 Software. Results： A total of 11 RCTs in three sub-groups in Chinese literatures were identified with meta-analyses in comparisons of the total effective rate RR=1.29, 95%CI [1.08, 1.54], total nasal symptoms scores MD=-2.09, 95%CI [-3.55, -0.62], the recurrence rate RR=0.31, 95%CI [0.22, 0.44]. The qualitative research indicated that there was a positive effect of Chinese medicine on improving the single nose symptom score. A total of four RCTs were included in the safety analysis, with no adverse reaction in three RCTs and with adverse reaction in one RCT. There was no significant difference in the occurrence rate between the above two groups. Conclusion： The current evidence shows that Chinese medicine in the treatment of AR could improve the clinical efficacy and the nasal symptoms and reduce the adverse reaction. But, due to the inferior quality of included trials, the accuracy of result may be influenced. So, the RCTs with large samples, scientific experimental design and high quality methodology should be required to provide more evidence for the efficacy and safety of Chinese medicine in the treatment of AR.

关 键 词：变应性鼻炎 中药 系统评价 META分析 随机对照实验 

分 类 号：R276.1[医药卫生—中医五官科学]