兰州地区家族性高脂蛋白血症家系特点分析  

Characteristics of familial hyperlipoproteinemia in Lanzhou

作　　者：刘维娟[1] 何津春[1,2] 王炜[3] 赵丽[4] 周兰霞[4] 

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院医学检验中心,甘肃兰州730000 [3]兰州大学信息科学与工程学院,甘肃兰州730000 [4]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《国际检验医学杂志》2014年第18期2437-2438,共2页International Journal of Laboratory Medicine

基　　金：国家"十五"重大科技专项资助项目(2002DA711A028-17);教育部科技基础平台建设资助项目(505015);甘肃省自然科学研究基金资助项目(1308RJZA218);甘肃省横向课题资助项目(2012620111000212)

摘　　要：目的调查兰州地区家族性高脂蛋白血症家系,了解该地区家族性高脂蛋白血症家系的特点。方法调查资料来自该课题的前期研究,筛选符合标准的高脂蛋白血症家系,收集入选家系成员调查表、体检及实验室数据,分析家族性高脂蛋白血症家系的特点。结果筛选出家族性高脂蛋白血症家系39个,共计280个家系成员。核心家系15个,单亲家系11个,父母双亡家系13个;家族性高胆固醇家系6个,家族性高三酰甘油血症家系9个,家族性混合型高脂血症家系24个。39个家系中子一代人数占全部家系所有成员的比例为63.2%,父辈所占比例为14.3%,子二代所占比例为22.5%。结论最常见的家族性高脂蛋白血症是家族性混合型高脂血症家系;血脂异常者中以子一代成员为主;核心家系数量少,不完整的非核心家系所占比例增加。Objective To investigate familial hyperlipoproteinemia and the features of familial hyperlipoproteinemia in Lanzhou . Methods Data were from previous studies on the subject .Families of hyperlipoproteinemia were screening ,questionnaires were col-lected ,physical examination and laboratory data of family members were also colleted to analysis the characteristics of familial hy-perlipoproteinemia .Results A total of 39 familial hyperlipoproteinemia families were enrolled in the study ,including 280 family members .There were 15 core families ,11 single-parent families ,and 13 orphaned families .There were 6 familial hypercholesterol-emia families ,9 familial hypertriglycerides families ,24 mixed familial hyperlipidemia families .The children of the first generation ac-counted for 63 .2% of the total number of people enrolled in the study ,the father generation accounted for 14 .3% ,the children of the second geration accounted for 22 .5% .Conclusion In the survey ,the most common type of familial hyperlipidemia was mixed familial hyperlipidemia .The father generation was majority .The member of core families was less than incomplete families .

关 键 词：家族性高脂蛋白血症 家系特点 甘肃 

分 类 号：R589.2[医药卫生—内分泌]