微生物慢性感染与冠状动脉病变程度的相关性研究  

The correlation between chronic infection of microorganism and the severity of coronary artery disease

作　　者：沈云峰[1] 张洪波[1] 胡远贵[1] 

机构地区：[1]武汉市第六医院检验科,湖北武汉430015

出　　处：《国际检验医学杂志》2014年第18期2457-2458,2461,共3页International Journal of Laboratory Medicine

基　　金：武汉市卫生局临床医学科研项目(WX11B14)

摘　　要：目的探讨肺炎衣原体、幽门螺杆菌、人类巨细胞病毒三种病原微生物的慢性感染与冠状动脉病变程度的关系,从而评价三者的抗体和超敏C反应蛋白(hs-CRP)检测对冠状动脉病变监测的价值。方法经冠状动脉造影证实冠状动脉没有明显狭窄者入选对照组,共37例;有一支血管狭窄者入选单支病变组,共36例;有两支血管狭窄者入选双支病变组,共30例;有大于两支血管狭窄者入选多支病变组,共29例。对四组纳入研究者分别进行血清肺炎衣原体、幽门螺杆菌、人类巨细胞病毒的IgG抗体及hs-CRP水平检测。结果对照组、单支病变组、双支病变组、多支病变组的肺炎衣原体、幽门螺杆菌、人类巨细胞病毒的IgG抗体阳性率及混合感染率之间的差异有统计学意义(P<0.05),IgG抗体滴度及hs-CRP浓度水平依次呈递增趋势,四组之间有统计学差异(P<0.05)。logistic回归分析表明三种微生物抗体阳性是冠状动脉病变发生、发展的危险因素。结论三种微生物的慢性感染对冠状动脉病变的发生及发展有一定影响。Objective To study the correlation between chronic infection of three microorganism and coronary artery lesion by detecting their antibodies and high-sensitivity C-reactive protein（hs-CRP） .Methods According to their severity of coronary artery lesion ,patients enrolled in the study were divided into 4 groups ,including normal control group（n=37） ,single-branch lesion group （n=36） ,double-branch lesion group（n= 30） and multi-branch lesion group（n= 29） .Serum Chlamydia pneumonia IgG（CPN-IgG） ,Helicobacter pylori IgG（HP-IgG） ,human cytomegalo virus IgG （HCMV-IgG） and hs-CRP tests were performed .Results CPN-IgG ,HP-IgG ,HCMV-IgG positive rates and the mixed infection positive rates increased sequentially from normal group to multi-branch group .There were significant differences of CPN-IgG ,HP-IgG ,HCMV-IgG and hs-CRP contents among the 4 groups （P〈0 .05） .Logistic analysis showed that CPN-IgG ,HP-IgG and HCMV-IgG were dangerous factors to coronary artery lesion . Conclusion Chronic infections of three microorganism might affect the development of coronary artery lesion .

关 键 词：肺炎衣原体 幽门螺杆菌 人类巨细胞病毒 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]