急性心肌梗死患者血浆LP(a) Hcy hs-CRP和cTnI水平检测的临床意义  

The clinical significance of plasma LP(a),Hcy,hs-CRP and cTnI concentrations determination in patients with acute myocardial infraction

作　　者：徐国新[1] 王芳 杨永青[3] 

机构地区：[1]苏州大学附属张家港市第一人民医院检验科,江苏张家港215600 [2]张家港市中医医院检验科,江苏张家港215600 [3]南京医科大学附属苏州市立医院核医学科,江苏苏州215002

出　　处：《国际检验医学杂志》2014年第18期2466-2468,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨急性心肌梗死(AMI)患者血浆脂蛋白(a)[Lp(a)]、同型半胱氨酸(Hcy),超敏C反应蛋白(hs-CRP)和肌钙蛋白I(cTnI)水平监测的临床应用。方法对162例AMI患者和165例健康体检者(对照组)进行血浆LP(a)、Hcy、hs-CRP和cTnI水平测定,并进行统计分析。结果 AMI患者治疗前的血浆LP(a)、Hcy、hs-CRP和cTnI水平与对照组比较,均显著增高(P<0.01)。在AMI患者治疗后,与对照组比较,97例治疗好转患者血浆hs-CRP恢复至正常水平(t=1.586,P>0.05),而血浆cTnI水平降低明显(t=3.322,P<0.01);36例治疗无效死亡患者血浆Hcy、hs-CRP和cTnI水平均明显升高(P<0.01)。结论血浆LP(a)、Hcy、hs-CRP和cTnI是治疗前诊断AMI有价值的指标,对患者治疗预后判断和随访最有价值的指标是血浆hs-CRP和cTnI。Objective To explore the clinical significance of plasma LP （a） ,Hcy ,hs-CRP and cTnI concentrations in patients with AMI .Methods Plasma LP（a） ,Hcy ,hs-CRP and cTnI concentrations of 162 patients with AMI and 165 healthy people recrui-ted as control group were determined .Immunofluorescent dry quantitative method and electro-chemiluminescence immunoassay were used in the determination ,and statistical analysis were used in data comparison .Results Before treatment ,the plasma LP（a） , Hcy ,hs-CRP and cTnI concentrations in 162 AMI patients were significantly higher than those in control group （P〈0 .01） .After treatment ,the plasma hs-CRP concentrations in 97 improved patients returned to normal （t=1 .586 ,P〉0 .05） ,but the plasma cTnI concentrations significantly decreased （t=3 .322 ,P〈0 .01） .The plasma Hcy ,hs-CRP and cTnI concentrations in 36 died patients were significantly higher（P〈0 .01） .Conclusion Plasma LP（a） ,Hcy ,hs-CRP and cTnI determination were valuable for the diagno-sis of AMI patients ,the most valuable indicators for patient prognosis and follow-up were plasma hs-CRP and cTnI .

关 键 词：急性心肌梗死 脂蛋白(a) 同型半胱氨酸 超敏C反应蛋白 肌钙蛋白I 

分 类 号：R541.4[医药卫生—心血管疾病]