养正消积胶囊真空带式干燥工艺优选  

Optimization of Vacuum-belt Drying Process of Yangzheng Xiaoji Capsules

作　　者：陈红专[1] 张静[1] 王青[1] 王燕臣 王晓楠[1] 

机构地区：[1]石家庄以岭药业股份有限公司,石家庄050035

出　　处：《中国实验方剂学杂志》2014年第21期38-40,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2011ZX09401-306)

摘　　要：目的:优化养正消积胶囊浸膏真空带式干燥的工艺参数。方法:采用HPLC-ELSD测定齐墩果酸含量,流动相乙腈-甲醇-0.5%乙酸(20∶70∶10)。以干膏含水率和齐墩果酸转移率为评价指标,采用正交试验考察进料速度、履带速度、加热系统温度对养正消积胶囊浸膏真空带式干燥工艺的影响。结果:最佳带式干燥工艺条件为履带速度6 cm·min-1,进料速度12 mL·min-1,干燥温度110℃,物料温度30℃,冷却区温度45℃,浸膏初始含固量约45%,真空度<-0.1 MPa;干膏含水率2.62%,RSD 1.2%;齐墩果酸转移率95.4%,RSD 0.42%。结论:优选的真空带式干燥工艺合理可行,干膏含水率低,质量好,适合养正消积胶囊的大生产推广。Objective：To optimize vacuum-belt drying process parameters of Yangzheng Xiaoji capsules extract.Method：HPLC-ELSD was employed to determine the content of oleanolic acid with mobile phase of acetonitrile-methanol-0.5％ acetic acid （20∶ 70∶ 10）.Taking water content of dry extract and transport rate of oleanolic acid as indicators,orthogonal design was adopted to investigate effects of feeding speed,belt speed and heating system temperature on vacuum-belt drying process of Yangzheng Xiaoji capsules.Result：Optimal parameters of vacuum-belt drying process were as follows：belt speed of 6 cm ·min-1,feeding speed of 12 mL· min-1 heating system temperature at 110 ℃ material temperature of 30 ℃ cooling zone temperature at 45 ℃ initial solid content in extract about 45％,vacuum degree ＜-0.1 MPa; moisture content of dry extract was 2.62％ with RSD of 1.2％ ; transfer rate of oleanolic acid was 95.4％ with RSD of 0.42％.Conclusion：This optimized technology is reasonable and feasible with low water content and good quality,which is suitable for large scale production of Yangzheng Xiaoji capsules.

关 键 词：养正消积胶囊 真空带式干燥法 齐墩果酸 含水量 

分 类 号：R283.6[医药卫生—中药学] R283.3[医药卫生—中医学]