近5年波罗蜜属植物化学成分及生物活性研究进展  

Advance on Chemical Constituents from Artocarpus Plant and Its Bioactivities in Recent Five Years

作　　者：任刚[1] 彭加兵 易文芳[1] 元文君 

机构地区：[1]江西中医药大学中药资源与民族药研究中心,南昌330004

出　　处：《中国实验方剂学杂志》2014年第21期234-239,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81160509;81360475);江西省教育厅科学技术研究项目(GJJ4614);江西省卫生厅中医药科研基金课题(2013A0029)

摘　　要：桑科波罗蜜属植物大多数为传统民间用药,具有较大的药用开发价值。近年来,波罗蜜属植物因富含具有显著生物活性的异戊烯基酚性成分而广受植物化学工作者的关注。通过SciFinder等数据库平台查阅国内外有关波罗蜜属植物的化学成分与药理作用的报道,对波罗蜜属植物的化学成分及其药理作用研究的内容进行文献整理和分析。结果表明,近5年来从波罗蜜属植物中获得70多个新化合物,大多为异戊烯基酚性化合物,其骨架类型包括黄酮类,二氢黄酮类、查尔酮类、二氢查尔酮类、双苯吡酮类、橙酮类、黄烷-3-醇类、2-芳基苯并呋喃类、1,2-二苯乙烯类;这些化合物具有抗炎、抗菌、抗氧化、抗肿瘤、细胞毒及抗锥虫及疟原虫、抑制胰脂肪酶、抑制酪氨酸酶、抑制黄嘌呤氧化酶、抑制α-葡糖苷酶和抑制黑色素生产生物活性,尤其是在抗氧化和细胞毒等方面效果显著。本文从化学成分结构和药理活性两方面对国内外波罗蜜属植物研究概况进行了综述,以期为该属植物的开发和利用提供参考。Most Artocarpus （Moraceae） plants are used as traditional folk medicine and have great medical value.In recent years,a large number of prenylated phenolic compounds with significant bioactivities were isolated from Artocarpus,which attracted many attentions of phytochemical researchers.The recent reports on chemical structures and pharmacological effects of chemical constituents from genus Artocarpus were searched by SciFinder and the retrieve results were analyzed.The results showed that more than 70 new compounds were reported from Artocarpus plants in recent five years.Most of these compounds is isoprenylated phenolic compounds,including flavones,flavanones,chalcones,dihydrochalcones,xanthones,aurones,flavan-3-ols,2-arylbenzofuran derivative,and 1,2-diphenylethylene.These compounds have anti-inflammatory,antibacterial,antioxidant,antitumor,cytotoxic,resistant trypanosomes and plasmodium,inhibiting pancreatic lipase,inhibiting tyrosinase,inhibiting xanthine oxidase,inhibiting-glucosidase and inhibiting melanin production activity.The paper reviews the new chemical compounds of Artocarpus plants and their bioactivities,which would provide references for the development and utilization of Artocarpus plants.

关 键 词：波罗蜜属 异戊烯基黄酮 非酚性成分 生理活性 

分 类 号：R284.1[医药卫生—中药学]