维吾尔族老年单纯收缩期高血压患者血清中晚期糖基化终产物与血管内皮功能的相关性研究  

Correlation study of serum advanced glycation end products with vascular endothelial function in Uygur elderly patients with isolated systolic hypertension

作　　者：李辰[1] 李玉桂[1] 黄榕[2] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]新疆维吾尔自治区人民医院干部保健二科

出　　处：《中国实用医刊》2014年第21期1-4,共4页Chinese Journal of Practical Medicine

基　　金：新疆维吾尔自治区自然科学基金（2011211A053）,新疆维吾尔自治区人民医院院内资助项目（20090108）

摘　　要：目的 探讨维吾尔族老年单纯收缩期高血压（ISH）患者血清中晚期糖基化终产物（AGE）与血管内皮功能的相关性.方法 选取118例维吾尔族老年ISH患者作为ISH组,维吾尔族老年原发性高血压（EH）患者115例作为EH组,并选择年龄与之相匹配的维吾尔族血压正常人群（NT） 100例作为NT组.采用ELISA法测定AGE浓度;采用Griess法测定血清一氧化氮（NO）浓度.应用超声技术测定血流介导的内皮依赖性血管舒张功能（FMD）,动脉硬化检测仪测定颈-股动脉脉搏波传导速度（cfPWV）.采用直线相关分析及多元线性逐步回归分析法分析AGE与其他指标的相关性.结果 ISH组、EH组AGE、cfPWV水平均高于NT组（P均＜0.05）,一氧化氮、FMD水平均低于NT组（P均＜0.05）,ISH组AGE及cfPWV水平均高于EH组（P均＜0.05）,ISH组一氧化氮、FMD均低于EH组（P均＜0.05）.相关性分析表明,AGE与cfPWV呈正相关（P＜0.001）;AGE与NO、FMD呈负相关（P均＜0.001）.多元线性逐步回归分析显示NO、cfPWV及AGE对FMD均有明显影响.结论 维吾尔族老年ISH患者血清AGE水平明显升高,且与FMD呈负相关。Objective To investigate the relationship between advanced glycation end products （AGE） and vascular endothelial function in Uygur elderly patients with isolated systolic hypertension （ISH）.Methods One hundred and eighteen Uygur old patients with ISH were enrolled as the ISH group,115 patients with essential hypertension （EH） were enrolled as the EH group,another 100 agematched normotension （NT） people were chose as NT group.Serum AGE levels were measured by ELISA method,and serum Nitric oxide（NO） levels were measured by Griess method.The flow-mediated endothelium-dependent vasodilation function （FMD） was detected by ultrasound technology,and carotid-femoral pulse wave conduction velocity （cfPWV） was measured by automatic arteriosclerosis detector.The relationship between AGE and other indicators was analyzed by linear correlation analysis and multiple linear stepwise regression analysis.Results The levels of AGE and cfPWV in ISH group and EH group were higher（P all ＜ 0.05）,while the levels of NO and FMD were lower than those in NT group （P all ＜ O.05）.The levels of AGE and cfPWV in ISH group were higher than those in EH group （P all ＜ 0.05）,while the levels of NO and FMD in ISH group were lower than those in EH group （P all ＜ 0.05）.AGE was positively correlated with cfPWV （P ＜ 0.001）,but was negatively correlated with NO and FMD （P all ＜ 0.001）.Multiple linear regression analysis showed that NO,cfPWV and AGE all had influence on FMD.Conclusions The serum AGE level is significantly elevated in Uygur elderly patients with isolated systolic hypertension,and it is negatively correlated with FMD.

关 键 词：维吾尔族 单纯收缩期高血压 晚期糖基化终产物 血流介导的内皮依赖性血管舒张功能 脉搏波传导速度 

分 类 号：R544.1[医药卫生—心血管疾病]