不同发病年龄原发性干燥综合征患者临床特点及免疫学指标的比较  

Comparisons of clinical and immunological characteristics of Primary Sjogren＇s syndrome with different Age of Onset

作　　者：李海波[1] 杨丽娟[1] 季晨[1] 

机构地区：[1]宁夏医科大学总医院风湿免疫科,宁夏750004

出　　处：《家庭心理医生》2014年第10期6-6,13,共2页Family Therapist

摘　　要：目的：探讨发病年龄不同的原发性干燥综合征（pSS）患者免疫学指标和临床特点的异同。方法：回顾性分析发病年龄不同的164例原发性干燥综合征患者的临床及实验室资料，按发病年龄将患者分为三组：〈45岁发病的青年患者，≥45岁〈60岁发病的中年患者及≥60岁发病的老年患者。结果：入选的干燥综合征患者共有164例，〈45岁发病的71例，≥45岁〈60岁发病的71例，≥60岁发病的22例。肺间质病变的发生率在青年发病患者为16．9％（12，71），中年为31．0％（22/71），而老年为54．5％（12／22），肺间质病变的发生率随诊年龄的增加而增加。〈45岁发病的青年患者其抗SSB抗体阳性率（52／71，73．2％）及RF阳性率（36／71，50．7％）在三个发病年龄组中最高。青年发病组IgG升高的发生率（46／71，64．8％）、中年发病为（47／71，66．2％），高于老年发病组（7／22，31．8％）。结论：pSS肺间质病变的发生是随着年龄的增加而增加；在自身抗体及免疫球蛋白方面，不同发病年龄组的pSS患者存在。Objective To study and compare the clinical and serological features of patients with different age of onset of Primary Sjogren＇s syndrome（pSS）. Methods We analyzed retrospectively 164 pSS patients who fulfilled the 2002 international classification （criteria） for pSS. They were subdivided into three groups according to the age at disease onset： elderly （t〉 60years）, middle-aged （i〉 45 and 〈 60years）, and young （〈 45years）. Clinical and immunological features of the disease were collected at time of diagnosis and then compared among the three groups. Results ① Among the 164 cases of pSS patients, youth group and middle-aged group were 72,the elderly group were 22. ② The incidence of pulmonary interstitial fibrosis increased with the age of onset. ③ The youth group＇s positive rate of anti-SSB antibody and RF was the highest in the three groups.As compared with disease onset older than 60,patients with disease onset younger than 60 had higher levels of IgG. Conclusion With growth of age,the incidence of pulmonary interstitial fibrosis was growing higher. In respect of autoantibodies and immnnoglobulin, there existed differences in different age of onset groups of patients with pSS.

关 键 词：原发性干燥综合征 发病年龄 

分 类 号：R969.4[医药卫生—药理学]