无抽搐电休克与利培酮治疗难治性精神分裂症的临床效果对照研究  

Comparative Study on the Clinical Effects of Risperidone and Modified Electroconvulsive Therapy for Refractory Schizophrenia

作　　者：饶世雄[1] 谭伟[1] 

机构地区：[1]四川省自贡市精神卫生中心,四川自贡643000

出　　处：《中国药物警戒》2014年第10期580-583,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨针对精神分裂症患者采用无抽搐电休克与利培酮药物治疗的临床效果比较。方法选取本院2012年10月～2013年10月收治的104例难治性精神分裂症患者作为研究对象，随机分为观察组与对照组各52例，观察组患者采用无抽搐电休克开展治疗，对照组患者给予利培酮药物治疗。观察两组样本治疗的远近期治疗效果、不良反应以及治疗成本，并开展比较与分析。结果两组患者治疗期间TESS评分与治疗有效率比较均无明显差异（P〉0．05），治疗后PANSS评分均好于治疗前（P〈0．05），但观察组治疗2周与4周的PANSS评分、治疗费用与成本一效果均明显好于对照组（P〈0．05）。结论针对难治性精神分裂症患者采用无抽搐电休克与利培酮药物治疗的有效性与安全性相当，但无抽搐电休克的起效速度与治疗成本更具优势。Objective To study the clinical effects of risperidone and modified electroconvulsive therapy for refractory schizophrenia. Methods 104 patients with refractory schizophrenia in our hospital from October 2012 to October 2013 were selected, randomly divided into the observation group and the control group with 52 cases for each one. Modified electroconvulsive therapy was used in the observation group. R_isperidone was used in the control group. Results Observation showed that TESS score and efficiency during treatment had no significant difference （P〉0.05）. After treatment, PANSS scores of two groups were better than before （P 〈0.05）. But PANSS scores of observation group in 2 week and 4 week were better than control group （P 〈0.05）. The cost of treatment was also better than control group （P 〈0.05）. Conclusion These results show that risperidone and modified electroconvulsive therapy for refractory schizophrenia have the equal efficacy and safety, but the speed of onset and treatment cost of modified electroconvulsive therapy have advantages.

关 键 词：难治性精神分裂症 利培酮 无抽搐电休克 

分 类 号：R453[医药卫生—治疗学]