小儿过敏性紫癜与肺炎支原体IgM阳性及C反应蛋白水平的临床分析  

Clinical analysis on pediatric henoch-schonlein purpura and mycoplasma pneumoniae IgM,C-reactive protein level

作　　者：胡志强 王海蓉[2] 

机构地区：[1]湖北省襄阳市第一人民医院,441000 [2]武汉大学中南医院,武汉430071

出　　处：《检验医学与临床》2014年第20期2828-2829,2832,共3页Laboratory Medicine and Clinic

基　　金：湖北省自然科学基金资助项目(2009CDB059)

摘　　要：目的分析小儿过敏性紫癜（HSP）与肺炎支原体（MP）感染、C反应蛋白（CRP）水平的关系,探讨小儿HSP感染后免疫球蛋白M（IgM）、CRP检测的意义。方法选择2010年7月至2013年7月襄阳市第一人民医院治疗的80例HSP患儿为观察组;另选同期80例体检的无感染性疾病的儿童为对照组,检测MP-IgM抗体的阳性率及血清CRP水平;对比观察组不同发病季节及不同年龄段患儿的MP-IgM阳性率、血清CRP水平。结果观察组患儿MP-IgM阳性率为61.25%,对照组阳性率为7.5%,差异有统计学意义（χ2=50.575,P〈0.01）。观察组患儿CRP为（19.28±12.16）mg/L,明显高于对照组的（6.18±4.29）mg/L,两组比较差异有统计学意义（P〈0.01）。患儿在1～2月发病时MP-IgM阳性率为78.37%,明显高于3～4月的42.86%和11～12月的48.28%,差异有统计学意义（F=7.441 3,P〈0.05）。3～7岁患儿MP-IgM阳性率为56.8%,高于0～3岁的40.9%及大于7岁的30.1%,差异具有统计学意义（P〈0.05）。结论 MP感染是小儿HSP的重要病因,不同季节患病、不同年龄段HSP患儿的MP-IgM阳性率不同,血清MP-IgM、CRP水平检测对HSP的临床诊断、治疗具有一定的指导意义。Objective To analyze the relationship between the pediatriz henoch-schonlein purpura（HSP）and Mycoplasma pneumoniae IgM （MP-IgM ） ,C-reactive protein levels ,and explore the significance of IgM positive test and C-reactive protein level detection in children with HSP .Methods A total of 80 children with henoch-schonlein purpura were selected as the observation group ,other 80 children without infection diseases as a control group .The MP-IgM antibodies and serum C-reactive protein levels were detected .The IgM positive rate and the levels of serum C-reactive protein of children at different ages and in different seasons .Results The IgM-positive rate of the obser-vation group was 61 .25% ,that of the control group was 7 .5% ,with significant difference between the two groups （χ2 = 50 .575 ,P〈 0 .01） .the C-reactive protein level in the observation group was （19 .28 ± 12 .16）mg/L ,which was significant higher than that of the control group（6 .18 ± 4 .29）mg/L（P〈 0 .01） .The IgM positive rate of children at-tacked HSP in January to February was 78 .37% ,which was significant higher than 42 .86% that of March to April and 48 .28% that of November to December （F= 7 .4413,P〈 0 .05） .The IgM positive rate of children at 3 ～ 7 years old was 57 .5% ,which was higher than 40 .0 % that of children with 0～3 years old and 26.7% that of children more than 7 years ,the differences were statistically significant （P〈 0 .05） .The C-reactive protein levels of the observation group was significant higher than that of the control group ,the difference was statistically significant （P 〈 0 .01） . Conclusion M P infection may be the effect factor of HSP in children .There were different IgM positive rates of chil-dren in different seasons and different ages .The positive rate of MP-IgM and serum C-reactive protein levels are the valuable diagnosis methods for henoch-schonlein purpura in children .

关 键 词：过敏性紫癜 肺炎支原体IGM C反应蛋白 

分 类 号：R692.34[医药卫生—泌尿科学]