国产比伐卢定在急诊介入治疗中对血小板功能的影响  

Impact of domestic bivalirudin on platelet function during emergency percutaneous coronary intervention

作　　者：王宇平[1] 郭金成[1] 张铭[2] 张海滨[1] 张学坤[1] 甘舜进[1] 高国旺[1] 张立新[1] 张正海[1] 蔡宜婷 唐宇[1] 柳子静[1] 

机构地区：[1]首都医科大学潞河教学医院心内科,北京101149 [2]首都医科大学附属北京安贞医院

出　　处：《心血管康复医学杂志》2014年第5期544-546,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨国产比伐卢定在急诊经皮冠状动脉介入治疗(PCI)中对血小板功能的影响。方法:100例急性ST段抬高性心肌梗死接受急诊PCI的患者随机分为肝素组(53例)和比伐卢定组(47例)。检测两组PCI术前后二磷酸腺苷(ADP)诱导的血小板聚集率,并进行统计学比较。结果:急诊PCI术前,两组ADP诱导的血小板凝聚率差异无统计学意义(P=0.99)。急诊PCI术后,比伐卢定组ADP诱导的血小板凝聚率显著低于肝素组[(16.46±10.23)%比(25.21±15.91)%,P<0.01]。结论:PCI术中,与常规肝素抗凝相比,作为抗凝剂的比伐卢定可以更明显抑制血小板凝聚,具有抗血小板的功能。Objective：To explore the impact of domestic bivalirudin on platelet function during emergency percutane-ous coronary intervention （PCI） .Methods ：A total of 100 patients with acute ST segment elevation myocardial in-farction who recieved emergency PCI were randomly divided into unfractionated heparin group （UFH group ,n=53） and bivalirudin group （n=47） .Adenyl diphosphoric acid （ADP）-induced platelet aggregation rate was meas-ured and statistically compared between two groups before and after PCI .Results：Before emergency PCI ,there was no significant difference in ADP-induced platelet aggregation rate between two groups （P=0.99） .After emergency PCI ,ADP-induced platelet aggregation rate in bivalirudin group was significantly lower than that of UFH group [ （16.46 ± 10.23）% vs .（25.21 ± 15.91） % , P〈0.01] .Conclusion：During percutaneous coronary intervention , compared with routine heparin anticoagulation , bivalirudin , as an anticoagulant , can more significantly inhibit platelet aggregation and possess antiplatelet effect .

关 键 词：心肌梗塞 血小板聚集 比伐卢定 

分 类 号：R542.22[医药卫生—心血管疾病]