非球形包膜微泡近场局部高压研究  

Localized high pressure near an aspheric encapsulated microbubble

作　　者：邵纬航[1] 陈伟中[1] 

机构地区：[1]南京大学声学研究所,近代声学教育部重点实验室,南京210093

出　　处：《物理学报》2014年第20期229-234,共6页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:11174145;11334005)资助的课题~~

摘　　要：基于流体力学,导出了超声驱动下的非球形包膜微泡的外部流体压强的解析表达式.数值模拟表明,虽然包膜微泡的非球形状对远场流体压强没有明显影响,但会造成近场局部位置有极大的流体压强,其明显高于同等条件下的球形包膜微泡周围相应位置上的流体压强.这一现象对包膜微泡的实际应用,如强超声治疗、靶向给药和细胞微穿孔等有着重要的意义.随着驱动频率向包膜微泡本征频率的靠近或微泡偏离球形程度的增大,所产生的近场局部高压也越大.Based on hydrodynamics, the pressure of the liquid outside an aspheric encapsulated bubble driven by ultrasound is studied, and its analytical expression is derived. Numerical simulation shows that 1） the aspheric shape of an encapsulated bubble makes little influence on the pressure of the liquid far away from the bubble; 2） the pressure is extremely high at some local places of the liquid near an aspheric encapsulated bubble, and the pressure values at these places are apparently larger than those for a sphericM encapsulated bubble at the same conditions. This phenomenon is of significance in the applications such as high intensity ultrasound therapy, drug delivery, cell membrane perforation, etc. As the ultrasound frequency shifts to the resonance frequency of an encapsulated bubble, or bubble shape deviates from sphericity, the localized high pressure becomes even greater.

关 键 词：非球形 包膜微泡 近场局部高压 

分 类 号：O35[理学—流体力学]