新疆维、汉民族P450arom、ER-β在宫颈鳞癌及癌前病变中的表达研究  

The expression of P450arom and ER-βin squamous cervical cancer and cervical intraepithelial neoplasia in Xinjiang Uygur and Han patients

作　　者：沈谷群[1] 袁建林[1] 程静新[1] 张国庆[1] 熊廷川[1] 

机构地区：[1]新疆医科大学附属肿瘤医院妇外三科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2014年第11期1470-1472,1476,共4页Journal of Xinjiang Medical University

基　　金：新疆乌鲁木齐市科技局科研项目(Y08131005)

摘　　要：目的探讨新疆维、汉民族宫颈鳞癌及宫颈鳞状上皮内瘤变(CIN)患者的宫颈病变组织中芳香化酶P450(P450arom)和雌激素β受体(ER-β)的表达,了解P450arom和ER-β在宫颈鳞癌及其癌前病变发生发展中的作用,以及其在维、汉族患者中的表达是否存在差异。方法收集宫颈鳞癌组、CIN组及对照组的石蜡标本180例,3组标本各60例,其中每组标本维、汉民族各30例。采用免疫组化的方法研究P450arom及ER-β在不同宫颈病变组织中的表达,以及其在维、汉族患者中的表达是否存在差异。结果 P450arom在对照组中的阳性表达率(17.9%)低于宫颈鳞癌组(55.0%)及CIN组(48.0%),差异有统计学意义(P=0.001);ER-β在对照组的阳性表达率57.9%,CIN组为37.3%,宫颈鳞癌组为15.3%,随着宫颈病变程度的增加,其表达呈递减的趋势,差异有统计学意义(P=0.000),但P450arom及ER-β在维、汉族患者中的表达差异无统计学意义。结论 :宫颈局部组织中的P450arom表达增高和ER-β表达降低,可能在促进宫颈鳞癌发生发展的过程中起到作用,但其在维、汉族患者中表达无差异。Objective To explore the expression of P450arom and ER-βwas in squamous cervical cancer and cervical intraepithelial neoplasia in Xinjiang Uygur and Han patients and to investigate their roles in the de-velopment of squamous cervical cancer （SCC）and cervical intraepithelial neoplasia （CIN）.Methods The expressions of P450arom and ER-βin 60 SCC specimens,60 CIN specimens and 60 adjacent normal cervical tissues were examined and explored by immunohistochemical method （S-P）to find the differences in the different grades of cervical lesions and differences in their expressions between Uygur and Han patients. Results The expression of P450arom in normal cervical tissues （17.9%）was lower than that in CIN （48%）and SCC （55%）,with significantly statistical difference （P =0.001）;the expression of ER-βwas 57.9% in normal cervical tissue,while 37.3% in CIN and 15.3% in SCC;with histologic grading in cervical lesions increasing,the expression of ER-βwas decreasing （P =0.000）;there were no differences in the ex-pression of P450arom and ER-β between Uyghur and Han ethnic groups.Conclusion The increasing ex-pression of P450arom and the decreasing expression of ER-β in cervical local tissue may lead to promoting squamous carcinogenesis but there were no differences in their expressions between Uyghur and Han patients.

关 键 词：宫颈鳞癌 宫颈鳞状上皮内瘤变 芳香化酶 P450 雌激素受体Β 

分 类 号：R711.74[医药卫生—妇产科学]