改良版柏林问卷用于鼾症门诊筛查阻塞性睡眠呼吸暂停低通气综合征高风险患者的评价  

Application of the modifi ed Berlin questionnaire to identify patients at high risk for obstructive sleep apnea among snoring outpatients

作　　者：戴娣[1,2,3] 刘子龙[1,2,3] 励雯静[1,2,3] 朱芬[1,2,3] 吴旭[1,2,3] 符翠萍[1,2,3] 张舒琪[1,2,3] 吴晓丹[1,2,3] 周新[4] 李善群[1,2,3] 

机构地区：[1]复旦大学附属中山医院呼吸科,上海200032 [2]复旦大学附属中山医院睡眠呼吸障碍与鼾症诊治中心,上海200032 [3]复旦大学呼吸病研究所,上海200032 [4]上海交通大学附属第一人民医院呼吸科,上海200080

出　　处：《世界临床药物》2014年第10期591-595,共5页World Clinical Drug

基　　金：上海市重点学科建设项目(编号:B115);上海市科委国际合作课题(编号:13430720500)

摘　　要：目的评估改良版柏林问卷(MBQ)在鼾症门诊筛查阻塞性睡眠呼吸暂停低通气综合征(OSAHS)高风险患者的作用。方法共312例鼾症门诊患者参与本研究,所有患者均填写MBQ,其中符合本研究入选标准的199例受试者在睡眠中心接受多导睡眠监测(PSG)。根据MBQ分数将受试者分为高危组和低危组,根据PSG监测结果将受试者分为非OSAHS组及轻、中、重度OSAHS组。分析由MBQ评分得出的危险度与呼吸暂停低通气指数(AHI)的关系,并行相关性分析。以PSG结果 AHI≥5为金标准,计算MBQ的敏感度、特异度、阳性预测值和阴性预测值等。结果根据MBQ结果,把患者分为OSAHS高风险组162例(81.4%)和低危组37例(18.6%),MBQ筛查OSAHS的敏感度为90.1%,特异度为46.8%。结论 MBQ在中国鼾症人群中具有较高的敏感性,可用于对门诊鼾症患者是否存在高风险OSAHS的初步筛查。Objective To evaluate the application of modifi ed Berlin questionnaire（MBQ） in detection of obstructive sleep apnea（OSAHS） for at-risk outpatients .Methods One hundred and ninty-nine subjects who completed the developed MBQ were selected for a full night PSG test. Based on MBQ score, these patients were classifi ed into both low and high risk group of OSAHS. According to PSG monitoring results, the patients were divided into non-OSAHS, mild, moderate and severe OSAHS groups. The correlation between MBQ and PSG results was analyzed through fourfold table. Results According to MBQ results, 162 patients（81.4%） belonged to OSAHS high risk group and 37 patients（18.6%） were OSAHS low risk group. The validation of MBQ against AHI at cutoff ≥ 5 revealed a sensitivity of 90.1%, specifi city of 46.8%. Conclusion MBQ has a high sensitivity in diagnosis of OSAHS risk for Chinese outpatients and it can be used by clinicians for OSAHS preliminary diagnosis.

关 键 词：改良版柏林问卷(MBQ) 阻塞性睡眠呼吸暂停低通气综合征(OSAHS) 筛查 多导睡眠监测 

分 类 号：R56[医药卫生—呼吸系统] R18[医药卫生—内科学]