新生儿缺氧缺血性脑病患者血清心肌酶谱及cTnI水平变化及临床意义  

The value of detection of serum myocardial enzyme spectrum and cardiac troponin I in neonatal hypoxic ischemic encephalopathy

作　　者：刘付明军 邱振华[1] 许军生 陈泽城[1] 

机构地区：[1]广东省高州市人民医院检验科,广东高州525200

出　　处：《国际检验医学杂志》2014年第19期2611-2612,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清心肌酶谱及心肌肌钙蛋白I(cTnI)检测在新生儿缺氧缺血性脑病(HIE)中的诊断意义。方法收集65例HIE患儿(HIE组),采用日立7602生化仪检测血清心肌酶谱水平,采用化学发光法检测血清cTnI水平,并以68例健康新生儿为对照组,分析各组心肌酶谱及cTnI水平变化情况。结果 HIE组天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶MB同工酶(CK-MB)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(HBDH)的水平,分别为(98.9±9.6)U/L、(385.4±15.5)U/L、(89.3±9.6)U/L、(300.8±19.8)U/L、(399.1±17.9)U/L,均明显高于对照组(P<0.05)。HIE组cTnI水平为(1.4±0.4)ng/mL,高于对照组(P<0.05)。CK-MB检测新生儿HIE的灵敏度为88.6%,cTnI检测新生儿HIE的特异性为86.3%。结论血清心肌酶谱及cTnI检测对新生儿HIE的诊断和治疗具有重要意义。Objective To discuss the value of analysis of serum myocardial enzyme spectrum and cardiac troponin I（cTnI） in neonatal hypoxic ischemic encephalopathy（HIE） .Methods Serum level of myocardial enzyme spectrum in each people was deter-mined with Hitachi 7602 ,Serum levels of cTnI was determined by chemoluminescence method .Serum levels of myocardial enzyme spectrum and cTnI were collect from 65 neonates with HIE（HIE group） and 68 cases of helthy volunteers（control group） .Results The levels of glutamic oxalacetic transaminase（AST） ,creatine kinase（CK） ,creatine kinase MB isoenzyme（CK-MB） ,lactic dehy-drogenase（LDH） and alpha-hydroxybutyric dehydrogenase（HBDH） in HIE group were（98 .9 ± 9 .6）U/L ,（385 .4 ±15 .5）U/L , （89 .3 ± 9 .6）U/L ,（300 .8 ± 19 .8）U/L ,（399 .1 ±17 .9）U/L ,which were higher than those in control group（P〈0 .05） .The level of cTnI was（1 .4±0 .4）ng/Ml in HIE group ,which was higher than that in control group（P〈0 .05） .CK-MB sensitivity was 88 .6% , cTnI speciality rate was 86 .3% .Conclusion The assay of myocardial enzyme spectrum and cTnI is significant in diagnosis of neo-natal HIE .

关 键 词：心肌酶谱 心肌肌钙蛋白I 新生儿缺氧缺血性脑病 

分 类 号：R473.72[医药卫生—护理学]