脑毒清颗粒对大鼠脑缺血再灌注损伤后IL-6和TNF-α含量的影响  

Effects of Naoduqing Granules on IL-6 and TNF-α Contents in Model Rats with Cerebral Ischemia-Reperfusion Injury

作　　者：曲颖[1] 王巍 贾维刚 王加志[3] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150001 [2]黑龙江省中医药科学院,黑龙江哈尔滨150001 [3]黑龙江中医药大学佳木斯学院,黑龙江佳木斯154000

出　　处：《中国中医急症》2014年第10期1823-1825,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：黑龙江哈尔滨市青年科技创新人才研究专项资金项目(2010RFQYS084)

摘　　要：目的观察脑毒清颗粒对脑缺血再灌注损伤的保护作用。方法大鼠随机分为对照组、假手术组、模型组和脑毒清组,采用线栓法(MCAO)制备大鼠大脑中动脉栓塞模型,2 h后抽取线栓对大鼠进行脑缺血再灌注,研究脑毒清颗粒对脑缺血再灌注神经功能缺损、脑梗死体积、血清中白细胞介素(IL-6)和肿瘤坏死因子(TNF-α)含量的影响。结果脑毒清颗粒能减少MCAO神经功能缺损评分和脑梗死体积,降低血中IL-6和TNF-α含量。结论脑毒清颗粒对大鼠脑缺血再灌注损伤有一定保护作用。Objective： To study the protective effects of Naoduqing granules on cerebral ischemia/reperfusion damage. Methods： Rats were randomly divided into control group, sham operation group,model group,and Nao- duqing granules group. Animal model of focal cerebral ischemia was established by using suture method in matUre SD rats. The neurological severity scores as well as the activity of IL-6 and TNF-α in brain tissue of cerebral is- chemia were detected. Results： In compared with the model group,the level of IL-6 and TNF-α were decreased with significant statistical differences in treatment group. Conclusion： Naoduqinggranules have obvious amelio-rating effect on focal cerebral ischemia in rats,which is caused by reduction of IL-6 and TNF-α contents.

关 键 词：脑毒清颗粒 缺血再灌注损伤 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R289.9[医药卫生—方剂学]