长效GnRH-a长方案在年轻患者COH中应用优势的探讨  

Discussion on Advantages of the Application of Long-acting GnRH-a by Long Protocol in Young Patients Undergoing Controlled Ovarian Hyperstimulation

作　　者：吴重聪[1] 杨桂艳[1] 阮永铭[1] 李利映[2] 

机构地区：[1]广东省珠海市妇幼保健院,广东珠海519000 [2]广东省梅州市人民医院

出　　处：《中国医学创新》2014年第29期7-10,共4页Medical Innovation of China

摘　　要：目的:通过比较促性腺激素释放激素(GnRH-a)长效长方案和短效长方案在控制性超排卵(COH)中应用的效果,探讨长效GnRH-a长方案在年轻患者体外受精-胚胎移植(IVF-ET)中应用的优势。方法:回顾性分析GnRH-a长效长方案(1045个周期)和GnRH-a短效长方案(555个周期)在年轻患者COH中应用的资料,按长方案降调节中使用长效或短效GnRH-a分为两组,观察比较两组超排卵效果及助孕结局。结果:在年轻患者中长效长方案组的促性腺激素(Gn)用量明显减少、超排时间延长、周期取消率升高,hCG日LH水平明显低于短效长方案组,获卵数、可移植胚胎数均明显多于短效长方案组,冷冻率明显高于短效长方案组,差异均有统计学意义(P<0.05),两组临床妊娠率比较无明显差异(P>0.05)。结论:对于年轻、卵巢储备正常的患者人群,长效长方案不失为控制性超排卵方案的一种好选择。Objective：To compare the application of long-acting and short-acting gonadotropin releasing hormone agonist（GnRH-a）by long down regulation protocol in controlled ovarian hyperstimulation（COH）,and to explore the advantages of the application of long-acting GnRH-a in young patients which undergoing in vitro fertilization and embryo transfer（IVF-ET）.Method：The data of young patients who adopted GnRH-a long protocol（1045 cycles received long-acting form of GnRH-a and 555 cycles received short-acting form of GnRH-a）in COH were analyzed retrospectively. Result：The dosage of gonadotropin（Gn）was significantly reduced in young patients who adopted long-acting GnRH-a, while the duration of Gn application was prolonged,cycle cancellation rates increased significantly,LH level in hCG day was significantly lower than that of short-acting group,the number of oocyte retrieved,the number of transferable embryo of long-acting group were significantly more than those of short-acting GnRH-a,and freezing rate of long-acting group was significantly higher than that of short-acting group,the differences were statistically significant（P〈0.05）.The two groups had no statistical difference between the clinical pregnancy rate（P〉0.05）.Conclusion：In the young patients with normal ovarian reserve,the application of long-acting GnRH-a by long down regulation protocol is a good choice.

关 键 词：促性腺激素释放激素激动剂 控制性超排卵 长方案 体外受精-胚胎移植 

分 类 号：R711.6[医药卫生—妇产科学]