小剂量他达拉非治疗糖尿病勃起功能障碍的疗效观察  

The Clinical Observation of Low-dose Tadalafil in Treatment of Diabetic Erectile Dysfunction

作　　者：周晓皮[1] 杨应国[1] 徐和平[1] 黄之前[1] 熊国根[1] 

机构地区：[1]南昌市医学科学研究所附属医院,江西南昌330001

出　　处：《中国医学创新》2014年第29期14-16,共3页Medical Innovation of China

摘　　要：目的:探讨小剂量他达拉非治疗糖尿病勃起功能障碍(ED)的临床疗效。方法:选取2013年1月-2014年2月来本院男科门诊就诊的96例糖尿病ED患者,按照随机数字表法将其分为治疗组和对照组各48例,治疗组给予小剂量他达拉非5 mg,每晚睡前1 h口服,连续使用3个月;对照组口服六味地黄丸8粒,3次/d,连续服用3个月。控制血糖的措施照常进行,保持有规律的性生活。治疗前后查血尿常规、肝肾功能、血糖及心电图,进行IIEF-5评分,指导患者记录性生活日记。结果:两组治疗前后血尿常规、肝肾功能、心电图、血糖均无明显变化(P>0.05),治疗组治疗后IIEF-5评分、阴茎插入成功率及维持勃起完成性交成功率均明显高于治疗前及对照组,差异均有统计学意义(P<0.01),而对照组以上各指标治疗前后差异均无统计学意义(P>0.05)。两组均未出现严重不良反应。结论:小剂量他达拉非治疗糖尿病ED安全有效,值得临床推广。Objective：To investigate the clinical effect of low-dose tadalafil in treatment of diabetic erectile dysfunction（ED）.Method：96 diabetic erectile dysfunction patients in clinic of Andrology from January 2013 to February 2014 were selected,they were divided into the treatment group and the control group according to the random number table method,48 cases in each group.The treatment group was treated with low-dose tadalafil（5 mg,taken 1 h before sleeping every night）for 3 months.The control group was treated with Liuwei Dihuang Wan（8 pill,Tid）for 3 months.The treatment of diabetes mellitus was taken as usual,sexual life was kept regularly.Blood and urine routine,the function of liver and kidney,blood glucose,ECG and international index of erectile function-5（IIEF-5）score were measured before and after treatment.The patient was taught to write sexual encounter profile.Result：Before and after the treatment,there was no exchange of blood and urine routine,the function of liver and kidney,blood glucose,ECG between two groups（P〉0.05）,IIEF-5 score,success rate of sexual penetration and success of sexual in the treatment group after treatment were significantly higher than those in before treatment and control group,the differences were statistically significant（P〈0.01）,but no statistical significance in the change of IIEF-5 score,success rate of sexual penetration and success of sexual in the control group（P〉0.05）.The two groups were no serious adverse reaction. Conclusion：Low-dose tadalafil is safe and effective in the treatment of diabetic erectile dysfunction,is worthy of clinical promotion.

关 键 词：他达拉非 糖尿病 勃起功能障碍 

分 类 号：R698.1[医药卫生—泌尿科学]