早期农民肺相关细胞因子研究进展与疾病预后  

Research progress on early farmer-lung related cytokines and disease prognosis

作　　者：毛世涛[1] 凌源[1] 王玲玲[1] 刘朔[1] 崔可慧 王笑歌[1] 

机构地区：[1]中国医科大学第四临床学院呼吸内科,辽宁沈阳110032

出　　处：《现代预防医学》2014年第21期3947-3950,共4页Modern Preventive Medicine

基　　金：国家十一五科技支撑项目<社区慢性阻塞性肺病(COPD)预防与控制适宜技术研究>[2007BAI24B004];沈阳市科技局<利用cDNA文库筛选大棚肺主要致病菌-热吸水链霉菌相关蛋白抗原并体外表达的相关研究>(F12-277-1-71);辽宁省科学技术计划项目(2013225303)

摘　　要：过敏性肺炎是一种由于反复吸入抗原而引起的炎性肺疾病,也称为外源性过敏性肺泡炎。抗原长期暴露出现肺泡淋巴细胞富集、肉芽肿性炎症、不可逆肺纤维化,发病率及死亡率逐年上升,农民肺越来越成为人们关注的焦点,投入的科研资源越来越来多。根据临床表现可分为3期(即:急性期,亚急性期和慢性期),不同时期,细胞因子作用存在差异。其中包括T淋巴细胞、肺泡巨噬细胞(AM)等多种细胞产生的TNF-α、IL、IFN-γ。本文对农民肺早期(急性期—亚急性期时期)主流的一些细胞因子变化情况进行综述。以期了解其特点及时机,探索有效的疾病防控措施、治疗方案及作出正确的预后判断。Hypersensitivity pneumonitis （HP） is a kind of inflammatory lung disease which is caused by repeated inhalation of antigen, also known as the extrinsic allergic alveolitis （EAA）. The long exposure to antigen causes the recruitment of alveolar lymphocytes, granulomatous inflammation, irreversible pulmonary fibrosis, increasing morbidity and mortality. Farmer-lung increasingly becomes widely concerned and more and more investment is spent for scientific research. According to clinical manifestations, it can be divided into three period （acute, subacute and chronic stage）. In different stages, there are different roles of cytokines, including TNF- α, IL, IFN- γ produced by T lymphocytes, alveolar macrophages （AM） and other cells. In this paper, the changes of some main cytokines are reviewed in the early farmer-lung （acute and subacute stages）, in order to understand its characteristics and timing, look for effective prevention and control measures, and make the right decision about disease prognosis.

关 键 词：农民肺 肺间质疾病 过敏性肺炎 发病机制 免疫学 细胞因子 

分 类 号：R113[医药卫生—公共卫生与预防医学]