IL-32在急性心肌梗死中的表达及与其它细胞因子表达水平的相关性  

The Correlation Between the Expression of IL-32 in Acute Myocardial Infarction and the Levels of Expression of Other Cytokines

作　　者：陈家林[1] 余小平[1] 夏小杰[1] 

机构地区：[1]深圳市第二人民医院,广东深圳518036

出　　处：《中外医疗》2014年第23期45-46,49,共3页China & Foreign Medical Treatment

基　　金：2012年深圳市科技计划项目(201203044)。项目名称:白细胞介素-32在急性心肌梗死中的表达及与其它细胞因子表达水平的相关性

摘　　要：目的探讨IL-32在急性心肌梗死中的表达及其与各细胞因子间的相关性。方法运用ELISA法测定36例急性心肌梗死患者以及30例对照组患者血清的水平,比较急性心肌梗死组与正常组IL-32、IL-1β、IL-6、IL-18、TNF-α和IL-10的表达情况,以及IL-32与各细胞因子间的相关性。结果急性心肌梗死组IL-32升高为(11.5±0.5)a,对照组的为(4.8±0.3),两组对比差异有统计学意义(P<0.05)。IL-1β、IL-6、IL-18、TNF-α和IL-10表达水平均也升高;提示IL-32与IL-1β、IL-6、IL-18、TNF-α和IL-10水平呈正相关。结论急性心肌梗死后,IL-32表达水平明显升高;IL-32与传统细胞因子IL-1β、IL-6、IL-18、TNF-α和IL-10表达水平呈正相关。Objective To investigate the correlation between the expression of interleukin-32（IL-32） in acute myocardial infarction and the levels of expression of other cytokines. Methods ELISA was used to detect the level of serum of 36 cases with acute my- ocardial infarction and 30 cases in the control group. The levels of expression of IL-32,IL-1β,IL-6,IL-18,TNF-α and IL-10 were compared between the acute myocardial infarction group and the control group. The relationships between IL-32 and other factors were also evaluated. Results The IL-32 of the acute myocardial infarction group increased to 11.5±0.5a, and the IL-32 of the control group was 4.8±0.3, the difference between the two groups was statistically significant （P〈0.05）. The expression levels of IL-113, IL-6, IL-18, TNF-α and IL-10 were all increased, which suggested that IL-32 was positively correlated with the levels of IL-1β, IL-6, IL-β, TNF-α and IL-10. Conclusion The expression level of IL-32 significantly increased after the occurrence of acute myocardial infarction, and IL-32 was positively correlated with the traditional cytokines such as IL-1β, IL-6, IL-18, TNF-β and IL-10.

关 键 词：白细胞介素-32 急性心肌梗死 炎症因子 

分 类 号：R543[医药卫生—心血管疾病]