甲氧苯基-乙基-苯并呋喃甲酮的制备条件优化  

Optimization of preparation conditions of methoxy-phenyl-ethyl-benzofuranyl-ketone

作　　者：王文龙[1] 王俊淞[2] 任方[1] 王沛[1] 韩怡然 冯乾坤[1] 孟庆和[1] 

机构地区：[1]长春中医药大学药学院,吉林长春130117 [2]昆明理工大学生命科学与技术学院

出　　处：《中国卫生工程学》2014年第5期411-413,共3页Chinese Journal of Public Health Engineering

基　　金：吉林省科技厅科技支撑项目(20120446)

摘　　要：目的优化甲氧苯基-乙基-苯并呋喃甲酮制备条件。方法选取甲氧苯基-乙基-苯并呋喃甲酮制得回收率为评价指标,以正交试验法L9(34)优选制备实验条件参数。结果原料投料比为1∶1,反应时间为3 h,反应温度为70℃。结论在所选因素水平范围内,原料投料比对本实验效果影响最大,所选条件制备工艺稳定、可行。Objective To optimize the experimental conditions of methoxy - phenyl - ethyl - benzofuranyl - ketone. Methods Methoxy phenyl ethyl benzofnranyl ketone was selected was evaluated as index system, experiment condi- tion parameters were optimized by orthogonal test L9 （34 ）. Results Raw material ratio was 1 ： 1, the reaction time was 3 hours, reaction temperature was 70℃. Conclusion Level within the scope of the selected factors, the greatest effect is ratio of raw material in this experiment. The selected conditions preparation process is stable and feasible.

关 键 词：制备工艺优化 正交设计 甲氧苯基-乙基-苯并呋喃甲酮 

分 类 号：R943[医药卫生—药剂学]