消痤胶囊对兔耳痤疮模型抗角化作用及血清睾酮、雌二醇含量的影响  

Effects of resolving acne capsule on anti-keratinization and the content of testosterone,estradiol in rabbit ear acne model

作　　者：张丽[1] 王凡[1] 尹小娥[1] 朱镭[2] 薛国娜 马拴全[1] 

机构地区：[1]陕西中医学院附属医院,陕西咸阳712000 [2]陕西中医学院

出　　处：《长春中医药大学学报》2014年第5期796-798,共3页Journal of Changchun University of Chinese Medicine

基　　金：陕西省科学技术研究发展计划项目"消痤胶囊药效物质及作用机制研究"(2012k-05-06)

摘　　要：目的观察消痤胶囊对兔耳痤疮模型毛囊皮脂腺导管的抗角化作用及对血清睾酮(T)、雌二醇(E2)含量的影响。方法将健康新西兰白兔随机分为消痤胶囊大、中、小剂量组、清热暗疮丸组、模型实验组、正常对照组,采用Kligman法建立兔耳痤疮模型,造模成功后分别灌饲消痤胶囊、清热暗疮丸和纯净水2周。通过肉眼和镜下病检观察皮损的角化情况,采用电化学发光法测定血清T、E2含量。结果消痤胶囊各剂量组和清热暗疮丸组均可不同程度的改善兔耳痤疮模型毛囊皮脂腺导管的异常角化,对血清T的含量有降低作用、对血清E2含量有升高作用,并呈量效关系。结论消痤胶囊可改善兔耳痤疮模型毛囊皮脂腺导管的异常角化,调节体内激素水平,对兔耳实验性痤疮有较好的治疗作用。Objective To observe the effect of resolving acne capsule on acne model of rabbit ear and the content of serum testosterone （T）,estradiol （E2）.Methods Rabbits were randomly divided into resolving acne capsule group in high dose, middle dose, low dose, Qingre Anchuang pill group, the model group, normal control group. The kligman method was used to build animal model, then given resolving acne capsule, Qingre Anchuang pill and pure water two weeks. The anti-keratosis actions of the tested drugs were observed by naked eye and by microscope, the serum testosterone and estradiol was measured by Electro-Chemiluminescence immunoassay （ECLI）. Results After giving resolving acne capsule and Qingre Anchuang pill 2 weeks later, the acne keratosis was suppressed and the level of testosterone was decreased, the level of estradiol was in- creased and showed dosage-effect relationship. Conclusion Resolving acne capsule can improve abnormal coruification of hair follicle and regulating hormone levels in acne model ofrabbits ear, resolving acne capsule has anti-acne effects.

关 键 词：消痤胶囊 痤疮 血清睾酮 雌二醇 

分 类 号：R285.5[医药卫生—中药学]