调和益胃颗粒制备工艺及质量标准研究  

Preparation technology and quality standards of the Tiaohe Yiwei Granules

作　　者：樊湘泽 姚金福[1] 姚文斌[1] 张天柱[1] 

机构地区：[1]长春中医药大学,长春130117

出　　处：《长春中医药大学学报》2014年第5期802-804,共3页Journal of Changchun University of Chinese Medicine

基　　金：吉林省中医药管理局中医药科技项目课题(2012-083)

摘　　要：目的研究调和益胃颗粒的制备工艺及质量标准。方法采用正交试验法选择与优化提取工艺及制粒条件;采用薄层色谱法对处方中的白术、莱菔子进行定性鉴别。结果水煎最佳条件为首次补足吸水量后浸泡1 h,其余每次加10倍量水,煎煮1 h,共3次;制粒工艺的最优条件为加入85%乙醇及β-环糊精适量,混合5 min。薄层色谱鉴别专属性强,且阴性对照无干扰。结论建立的提取工艺、颗粒制备工艺稳定可靠,制剂质量标准灵敏度高,专属性强,为调和益胃颗粒的临床用药和进一步开发利用提供理论依据和技术支撑。Objective To study the preparation technology and quality standards of the Tiaoheyiwei Granules. Methods The orthogonal test method was used to choose and optimize the extraction process and granulation conditions;the thin layer chromatography （TLC） was introduced to identify White atractylodes rhizome and Semen raphani in the prescription. Results When the first soakage was complemented, it was soaked for 1 hour and 10 times the amount of water was added. And then it was decocted for 1 hour for 3 times;the optimal conditions for granulation process were described as follows：85 % ethanol and appropriate ^-ring dextrin were added and mixed for 5minutes. TLC had a good specialization and there was no interference when compared with the negative. Conclusion The established extraction process and particle preparation process were stable and reliable;the quality standards of preparation had a high sensitivity and specialization. This method provided the theoretical basis and technical support for further development of the clinic medication of Tiaoheyiwei Granules.

关 键 词：调和益胃颗粒 制备工艺 正交试验 薄层色谱鉴别 

分 类 号：R285.1[医药卫生—中药学]