Th17及相关细胞因子在哮喘中的作用研究  

Research on the role of Th17 and related cytokines in asthma

作　　者：凌昊[1] 赵霞[1] 

机构地区：[1]南京中医药大学,南京210029

出　　处：《长春中医药大学学报》2014年第5期930-933,共4页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金项目(81173299);国家重点学科课题(EZK2012005);江苏省研究生培养创新工程项目课题(CXLX13-584)

摘　　要：Th17细胞是近来发现的一类不同于Th1,Th2的另一种CD4+T细胞的新亚型,在自身免疫病、感染等疾病中发挥重要的作用,TH17相关细胞因子如IL-17,IL-23,TGF-β等能够加重气道炎症及促进气道重塑,气道炎症反应又能够破坏Th17/Treg平衡,从而促进哮喘发作。因此以Th1/Th2/Th17等为靶点,通过抑制或者调节这些细胞的功能,从炎症反应的上游进行阻断、调节Th17/Treg平衡,影响哮喘基因调控及编码的蛋白,进而改善体质,为哮喘的治疗开辟新的道路。Th17 cell is recently discovered as a new subtype of CD4＋T cell which is different from Th2 cells. It plays an im- portant role in autoimmune disease and infectious disease. TH17 related cytokines such as IL-17, IL-23, IGF-β can aggravate airway inflammation and promote airway remodeling, which could destroy the Thl7/Treg balance, so as to promote an asthma attack. Therefore, with Th1/Th2/Th17 as the target, researchers could regulate Th17/Treg balance and improve physique fit- ness by inhibiting or regulating the functions of these cells to influence asthma gene regulation and protein coding, thus to open up a new way for the treatment of asthma.

关 键 词：TH细胞 相关因子 哮喘/中医药疗法 

分 类 号：R256.12[医药卫生—中医内科学]