维吾尔族和汉族人群高尿酸血症影响因素病例对照研究  

Risk factors of hyperuricemia in Uygur and Han population:a case-control study

作　　者：王婷婷[1] 苗蕾[1] 马琦[2] 马艳[1] 苏银霞[1] 姚华[2] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院代谢性疾病重点实验室

出　　处：《中国公共卫生》2014年第11期1424-1428,共5页Chinese Journal of Public Health

基　　金：国家重点基础研究发展计划(973计划)(2012CB722403);新疆重大疾病重点实验室开放课题(SKLIB-XJMDR-2012-Y4);新疆研究生科研创新基金(XJGRI2013083)

摘　　要：目的了解新疆维吾尔族和汉族人群高尿酸血症患病的影响因素,为采取相应干预措施提供科学依据。方法采用以医院为基础的病例对照研究方法,对2012年2—12月在新疆医科大学第一附属医院住院的825例高尿酸血症患者和同期在该院体检的1 001名非高尿酸血症及痛风者进行问卷调查、体格检查和实验室检测。结果维吾尔族人群病例组吸烟、饮酒、肥胖、血脂紊乱、高胆固醇血症者的比例分别为51.35%、53.15%、48.20%、69.82%、24.32%,均高于对照组的24.24%、33.21%、36.27%、49.73%、18.67%,经常运动者的比例为20.00%,低于对照组的62.30%,差异均有统计学意义(均P<0.05);汉族人群病例组的吸烟、饮酒、经常吃肉、肥胖、血脂紊乱、高胆固醇血症、高血压、高血糖者的比例分别为55.91%、59.58%、83.99%、25.46%、76.64%、38.06%、21.26%、17.85%,均高于对照组的38.51%、47.07%、76.35%、7.88%、44.59%、23.42%、9.23%、24.77%,经常运动者的比例为23.36%,低于对照组的44.59%,差异均有统计学意义(均P<0.05);多因素条件logistic回归分析结果显示,吸烟、饮酒、肥胖、血脂紊乱是维吾尔族人群高尿酸血症患病的危险因素,经常运动是其保护因素;吸烟、肥胖、高血压、血脂紊乱、高胆固醇血症是汉族人群高尿酸血症患病的危险因素,经常运动是其保护因素。结论不同民族人群高尿酸血症患病的影响因素存在差异,其中是否吸烟、肥胖、血脂紊乱和经常运动是维吾尔族和汉族人群高尿酸血症患病的共同影响因素。Objective To investigate risk factors of hyperuricemia among Uygur minority and Han nationality in Xinjiang Uygur Autonomous Region（Xinjiang）,and to provide scientific basis for making intervention measures.Methods With questionnaire survey,physical examination and laboratory test,a hospital-based case-control study was conducted among 825 inpatients of hyperuricemia aged between20 to 70 years from the First Affiliated Hospital of Xinjiang Medical University during February to December 2012 and1001 age-matched physical examinees in the same hospital and during the same period.Results The ratios of smoking,alcohol drinking,lack of exercise,obesity,dyslipidemia,and hypercholesterolemia in the Uygur minority cases were 51.4%,53.2%,80.0%,48.20%,69.82%,and 24.32% and all of which were higher than those of the controls（24.2%,33.2%,37.7%,36.27%,49.73%,and 18.67%;P〈0.05 for all）.The ratios of smoking,alcohol drinking,regular intake of meat,lack of exercise,obesity,dyslipidemia,hypercholesterolemia,hypertension,and hyperglycemia in Han nationality cases were 55.9%, 59.6%, 84.0%, 76.6%, 25.46%, 76.64%,38.06%,21.26%,and 17.85%and also were all higher than those of the comtrol（38.5%, 47.1%, 76.4%, 55.4%, 7.88%, 44.59%, 23.42%, 9.23%, and 24.77%;P〈0.05 for all）.Multivariate conditional logistic regression analyses showed that the risk factors of hyperuricemia for Uygur minority were smoking（odds ratio[OR]=2.71,95%confcdence interval[95%CI]：1.98-3.715）,alcohol drinking（OR=1.58,95%CI：1.164-2.148）,obesity（OR=1.60,95%CI：1.186-2.148）,dyslipiemia（OR=1.743,95%CI：1.289-2.357）,with regular exercise as a protective factor（OR =0.157,95%CI：0.115-0.213）.The risk factors of hyperuricemia for Han nationality were smoking（OR=1.637,95%CI：1.181-2.270）,hypertension（OR=1.757,95%CI：1.117-2.766）, obesity（OR=3.003,95%CI：1.917-4.706）,dyslipidemia（OR=2.900,95%CI：2.082-4.040）,and hypercholesterolemia（OR=1.773,95%CI：1.261-2.491）, with regular exercise as a protective factor（O

关 键 词：高尿酸血症 影响因素 维吾尔族 汉族 病例对照研究 

分 类 号：R589.7[医药卫生—内分泌]