妊娠期高血压疾病患者血浆总同型半胱氨酸与维生素B_(12)水平的关系  

Relationship between plasma total homocysteine level and serum vitamin B_(12) level in patients with hypertensive disorder complicating pregnancy

作　　者：吴敬伟 陈淑学 

机构地区：[1]河北省秦皇岛市抚宁县中医院,066600 [2]河北省秦皇岛市妇幼保健院,066000

出　　处：《中国妇幼保健》2014年第31期5048-5050,共3页Maternal and Child Health Care of China

基　　金：河北省秦皇岛市科技计划项目〔2012023A211〕

摘　　要：目的:测定妊娠期高血压疾病患者血浆总同型半胱氨酸(t HCY)和维生素B12水平,以探讨该疾病患者血浆中2者之间的关系。方法:血浆t HCY水平测定采用荧光偏振免疫分析法,血清中维生素B12水平测定采用微粒子酶联免疫分析法。结果:232例妊娠期高血压疾病患者血浆t HCY水平和血清维生素B12水平为(12.46±3.98)μmol/L和(352.35±97.67)pmol/L,232例同期正常妊娠妇女血浆t HCY水平、血清中叶酸和维生素B12水平分别为(6.71±2.43)μmol/L和(438.63±129.45)pmol/L,2组比较均具有统计学差异(P<0.01)。97例重度妊娠期高血压疾病患者血浆中t HCY、血清叶酸及维生素B12水平分别为(15.07±5.22)μmol/L和(315.29±84.17)pmol/L,135例轻度妊娠期高血压疾病患者血浆中t HCY水平、血清中叶酸及维生素B12水平分别为(10.28±3.73)μmol/L和(390.23±114.34)pmol/L,2组比较均具有统计学差异(P<0.01)。相关分析发现,2组血浆t HCY水平与维生素B12水平均为负相关性。结论:妊娠期高血压疾病患者血浆中t HCY浓度呈显著性上升,维生素B12浓度呈显著性下降。伴随病情加重妊娠期高血压疾病患者血浆t HCY浓度呈上升趋势,血清叶酸、维生素B12浓度呈下降趋势。Objective： To detect the levels of plasma total homocysteine （tHCY） and serum vitamin B t2 in patients with hyperten- sive disorder complicating pregnancy （HDCP） , explore the relationship between plasma tHCY level and serum vitamin BI2 level. Methods： Fluorescence polarization immunoassay was used to detect the level of plasma tHCY, lnicroparticle i,nmunoassay with ELISA was used to detect the level of serum vitamin B12. Results： The levels of plasma tHCY and serum vitamin Bj2 in 232 patients with HDCP were （ 12.46 ± 3.98） μmol/L and （352. 35 ±97.67） μmol/L; the levels of plasma tHCY and sermn vitamin B,2 in 232 normal pregnmlt women during the same period were （6. 71 ± 2.43 ）μmol/L and （438.63 ± 129.45 ）μmol/L, there were statistically significant differences between the two groups （ P 〈 0.01 ） . The levels of plasma tHCY and serum vitamin B12 in 97 patients with severe HDCP were （ 15.07 ± 5.22） μmol/L and （315.29 ± 84. 17 ）μmol/L; the levels of plasma tHCY and serum vitamin B12 in 135 patients with mild HDCP were （ 10. 28± 3.73 ） μmol/L and （ 390. 23 ± 114. 34） μmol/L, there were statistically sigi,ificant differences between the two groups （ P 〈 0. 01 ） . There was a negative eolTelation between plasma tHCY level and serum vitamin B12 level. Conclusion： Plasma tHCY level increa- ses sigafificantly in patients with HDCP, while the level of vitamin B12 decreased significantly. With the aggravation of HDCP, plasma tHCY level shows increasing trend, while serum vitamin B12 level shows decreasing trend.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 维生素B12 

分 类 号：R714.246[医药卫生—妇产科学]